The 2001 Primera División Uruguaya was contested by 18 teams, and Nacional won the championship.
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Nacional | 6 | 4 | 1 | 1 | 13 | 6 | +7 | 13 |
| 2 | Danubio | 6 | 4 | 1 | 1 | 14 | 9 | +5 | 13 |
| 3 | Bella Vista | 6 | 3 | 2 | 1 | 13 | 7 | +6 | 11 |
| 4 | Cerro | 6 | 2 | 2 | 2 | 10 | 7 | +3 | 8 |
| 5 | Fénix | 6 | 2 | 1 | 3 | 8 | 9 | −1 | 7 |
| 6 | Rentistas | 6 | 2 | 0 | 4 | 5 | 12 | −7 | 6 |
| 7 | River Plate | 6 | 0 | 1 | 5 | 4 | 17 | −13 | 1 |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Peñarol | 5 | 4 | 1 | 0 | 8 | 3 | +5 | 13 |
| 2 | Defensor Sporting | 5 | 2 | 1 | 2 | 10 | 9 | +1 | 7 |
| 3 | Central Español | 5 | 2 | 1 | 2 | 10 | 9 | +1 | 7 |
| 4 | Racing Montevideo | 5 | 2 | 1 | 2 | 5 | 7 | −2 | 7 |
| 5 | Montevideo Wanderers | 5 | 1 | 2 | 2 | 9 | 11 | −2 | 5 |
| 6 | Huracán Buceo | 5 | 0 | 2 | 3 | 5 | 8 | −3 | 2 |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Juventud Las Piedras | 4 | 2 | 1 | 1 | 5 | 3 | +2 | 7 |
| 2 | Paysandú Bella Vista | 4 | 1 | 2 | 1 | 3 | 3 | 0 | 5 |
| 3 | Deportivo Maldonado | 4 | 1 | 2 | 1 | 2 | 2 | 0 | 5 |
| 4 | Tacuarembó | 4 | 1 | 2 | 1 | 4 | 5 | −1 | 5 |
| 5 | Rocha | 4 | 1 | 1 | 2 | 5 | 6 | −1 | 4 |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Peñarol | 17 | 12 | 3 | 2 | 30 | 16 | +14 | 39 |
| 2 | Danubio | 17 | 11 | 5 | 1 | 42 | 24 | +18 | 38 |
| 3 | Defensor Sporting | 17 | 11 | 3 | 3 | 42 | 22 | +20 | 36 |
| 4 | Nacional | 17 | 8 | 7 | 2 | 37 | 20 | +17 | 31 |
| 5 | Bella Vista | 17 | 9 | 4 | 4 | 36 | 24 | +12 | 31 |
| 6 | Fénix | 17 | 9 | 2 | 6 | 31 | 21 | +10 | 29 |
| 7 | Montevideo Wanderers | 17 | 7 | 6 | 4 | 27 | 20 | +7 | 27 |
| 8 | Tacuarembó | 17 | 5 | 7 | 5 | 22 | 22 | 0 | 22 |
| 9 | Central Español | 17 | 5 | 5 | 7 | 27 | 26 | +1 | 20 |
| 10 | Racing Montevideo | 17 | 5 | 5 | 7 | 18 | 24 | −6 | 20 |
| 11 | Cerro | 17 | 5 | 4 | 8 | 23 | 20 | +3 | 19 |
| 12 | Juventud Las Piedras | 17 | 5 | 3 | 9 | 16 | 24 | −8 | 18 |
| 13 | Rentistas | 17 | 5 | 3 | 9 | 14 | 29 | −15 | 18 |
| 14 | Paysandú Bella Vista | 17 | 3 | 7 | 7 | 15 | 26 | −11 | 16 |
| 15 | Huracán Buceo | 17 | 3 | 6 | 8 | 25 | 31 | −6 | 15 |
| 16 | River Plate | 17 | 3 | 6 | 8 | 11 | 25 | −14 | 15 |
| 17 | Deportivo Maldonado | 17 | 3 | 5 | 9 | 13 | 32 | −19 | 14 |
| 18 | Rocha | 17 | 2 | 3 | 12 | 17 | 40 | −23 | 9 |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Danubio | 9 | 7 | 1 | 1 | 17 | 4 | +13 | 22 |
| 2 | Peñarol | 9 | 6 | 3 | 0 | 18 | 7 | +11 | 21 |
| 3 | Nacional | 9 | 6 | 0 | 3 | 15 | 9 | +6 | 18 |
| 4 | Montevideo Wanderers | 9 | 5 | 2 | 2 | 14 | 11 | +3 | 17 |
| 5 | Defensor Sporting | 9 | 3 | 4 | 2 | 20 | 15 | +5 | 13 |
| 6 | Fénix | 9 | 4 | 1 | 4 | 16 | 13 | +3 | 13 |
| 7 | Tacuarembó | 9 | 2 | 2 | 5 | 9 | 14 | −5 | 8 |
| 8 | Bella Vista | 9 | 2 | 0 | 7 | 12 | 20 | −8 | 6 |
| 9 | Paysandú Bella Vista | 9 | 1 | 2 | 6 | 5 | 19 | −14 | 5 |
| 10 | Juventud Las Piedras | 9 | 1 | 1 | 7 | 10 | 24 | −14 | 4 |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Nacional | 9 | 6 | 3 | 0 | 19 | 7 | +12 | 21 |
| 2 | Danubio | 9 | 6 | 0 | 3 | 19 | 13 | +6 | 18 |
| 3 | Peñarol | 9 | 5 | 1 | 3 | 11 | 10 | +1 | 16 |
| 4 | Defensor Sporting | 9 | 4 | 1 | 4 | 15 | 18 | −3 | 13 |
| 5 | Montevideo Wanderers | 9 | 3 | 3 | 3 | 12 | 10 | +2 | 12 |
| 6 | Juventud Las Piedras | 9 | 3 | 4 | 2 | 12 | 11 | +1 | 10[a] |
| 7 | Tacuarembó | 9 | 3 | 1 | 5 | 9 | 9 | 0 | 10 |
| 8 | Fénix | 9 | 2 | 4 | 3 | 10 | 12 | −2 | 10 |
| 9 | Paysandú Bella Vista | 9 | 2 | 3 | 4 | 13 | 18 | −5 | 9 |
| 10 | Bella Vista | 9 | 1 | 0 | 8 | 8 | 20 | −12 | 3 |
Nacional won the championship.
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Central Español | 31 | 13 | 9 | 9 | 49 | 35 | +14 | 48 |
| 2 | Cerro | 31 | 12 | 8 | 11 | 48 | 36 | +12 | 44 |
| 3 | River Plate | 31 | 8 | 13 | 10 | 25 | 37 | −12 | 37 |
| 4 | Racing Montevideo | 31 | 7 | 12 | 12 | 32 | 45 | −13 | 33 |
| 5 | Rentistas | 31 | 8 | 7 | 16 | 29 | 51 | −22 | 31 |
| 6 | Huracán Buceo | 31 | 5 | 11 | 15 | 37 | 53 | −16 | 26 |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Deportivo Maldonado | 31 | 8 | 9 | 14 | 31 | 49 | −18 | 33 |
| 2 | Rocha | 31 | 6 | 8 | 17 | 35 | 59 | −24 | 26 |