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Artemotil





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Artemotil (INN; also known as β-arteether[1]), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases.[2] It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.

Artemotil
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • not available
Routes of
administration		Intramuscular injection
ATC code
Pharmacokinetic data
MetabolismHepatic
Elimination half-life20 hours
Identifiers

  • (5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene

CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC17H28O5
Molar mass312.406 g·mol−1
3D model (JSmol)

  • CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C

  • InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1 ☒N

  • Key:NLYNIRQVMRLPIQ-XQLAAWPRSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

References

  1. ^ "The International Pharmacopoeia - Sixth Edition - Artemotil" (PDF). 2016. Retrieved 10 April 2019.
  • ^ Yeates RA (April 2002). "Artemotil Artecef". Current Opinion in Investigational Drugs. 3 (4). London, England: 545–9. PMID 12090721.
    •  

    This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

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    Last edited on 30 May 2023, at 01:39  





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    ●This page was last edited on 30 May 2023, at 01:39 (UTC).
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