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{{Short description|Variety of maize}}
'''MON 863''' is a [[genetic engineering|genetically engineered]] variety of [[maize]] produced by [[Monsanto]].
'''MON 863''' is a [[Genetically modified maize|genetically engineered variety of maize]] produced by [[Monsanto]]. It is genetically altered to express a modified version of [[Cry3Bb1]], a delta endotoxin which originates from ''[[Bacillus thuringiensis]]''.<ref name='Greenpeace MON863 chronicle'>{{cite web | url = http://www.greenpeace.org/international/Global/international/planet-2/report/2007/3/mon863_chronicle_of_deception.pdf | title = The MON863 case - a chronicle of systematic deception | accessdateaccess-date = 2010-07-22 | format = PDF | publisher = [[Greenpeace]] | quote = MON863 is a genetically modified corn that expresses a Bt-toxin. This toxin is a modified version of the delta endotoxin Cry3Bb1 which originates from the microorganism Bacillus thuringiensis. The genetic manipulation is aimed at protecting maize plants against a pest called corn rootworm (Diabrotica spp.). MON863 differs from other Bt-corns already placed on the market (MON810, BT11, Bt176), which produce a modified Cry1Ab toxin conferring resistance to a pest called European corn borer (Ostrinia nubilalis), in that it produces an artificial Cry3Bb1 toxin. In addition to the modified Cry3Bb1 toxin gene MON863 contains an antibiotic resistance marker gene.}}</ref><ref name='Doull 2007 genetics'>{{cite journal |doi=10.1016/j.fct.2007.08.033 |title=Report of an Expert Panel on the reanalysis by of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863) |year=2007 |last1=Doull |first1=J. |last2=Gaylor |first2=D. |last3=Greim |first3=H.A. |last4=Lovell |first4=D.P. |last5=Lynch |first5=B. |last6=Munro |first6=I.C. |journal=[[Food and Chemical Toxicology]] |volume=45 |issue=11 |pages=2073–85 |pmid=17900781}}</ref> This protects the plant from [[Diabrotica|corn rootworm]].<ref name='Doull 2007 genetics' /><ref name='Coghlan 2010-01-22'>{{cite news | first = Andy | last = Coghlan | title = Engineered maize toxicity claims roundly rebuffed | date = 2010-01-22 | url = httphttps://www.newscientist.com/article/mg20527444.000-engineered-maize-toxicity-claims-roundly-rebuffed.html | work = New Scientist | accessdateaccess-date = 2010-07-21}}</ref> Unlike [[MON 810]], [[Bt 11]], and [[Bt 176]] which each produce a modified [[Cry1Ab]], MON 863 instead produces a modified Cry3Bb1 toxin and contains [[nptII]], a [[marker gene]] for [[antibiotic resistance]].<ref name='Greenpeace MON863 chronicle' /><ref name='Lorch 2005-09-30'>{{cite web | url = http://www.ifrik.org/files-ifrik/0509_greenpeace_mon863_hybrids.pdf | title = EFSA’sEFSA's Opinion on MON863 hybrids | accessdateaccess-date = 2010-07-22 | last = Lorch | first = Antje | date = 2005-09-30 | format = PDF | work = ifrik | publisher = [[Greenpeace]] | quote = MON863 contains an GM antibiotic resistance gene (nptII) against kanamycin and neomycin. | url-status = dead | archive-url = https://web.archive.org/web/20110726171634/http://www.ifrik.org/files-ifrik/0509_greenpeace_mon863_hybrids.pdf | archive-date = 2011-07-26 }}</ref>
 
==History==
In 2004, Monsanto sought approval in Europe to introduce MON 863. Approval was granted in 2005 for use in feed<ref>Staff (8 August 2005) [http://www.gmo-compass.org/pdf/regulation/maize/MON863_maize_decision_feed.pdf concerning the placing on the market, in accordance with Directive 2001/18/EC of the European Parliament and of the Council, of a maize product (Zea mays L., line MON 863) genetically modified for resistance to corn rootworm] {{Webarchive|url=https://web.archive.org/web/20101231200535/http://www.gmo-compass.org/pdf/regulation/maize/MON863_maize_decision_feed.pdf |date=2010-12-31 }} Commission of the European Communities, Official Journal, Retrieved 17 November 2012</ref> and in 2006 for use in food.<ref>Staff (13 January 2006) [http://www.gmo-compass.org/pdf/regulation/maize/MON863_maize_decision_food.pdf concerning the placing on the market, in accordance with Directive 2001/18/EC of the European Parliament and of the Council, of a maize product (Zea mays L., line MON 863) genetically modified for resistance to corn rootworm and in 2006 in food] {{Webarchive|url=https://web.archive.org/web/20120905152527/http://www.gmo-compass.org/pdf/regulation/maize/MON863_maize_decision_food.pdf |date=2012-09-05 }} Commission of the European Communities, Official Journal, Retrieved 17 November 2012</ref> There was controversy over acceptance by regulatory bodies of industry-funded toxicity studies and over the design of those studies led by Pr [[Gilles-Éric Séralini]], who was on the committee that reviewed MON863 for the French government.<ref>{{Cite web |url=http://www.criigen.org/SiteEn/index.php?option=com_content&task=view&id=57&Itemid=105 |title=Seralini bio on CRIIGEN |access-date=2012-09-22 |archive-url=https://web.archive.org/web/20140330131455/http://www.criigen.org/SiteEn/index.php?option=com_content&task=view&id=57&Itemid=105 |archive-date=2014-03-30 |url-status=dead }}</ref>
 
See [[genetically_modified_food_controversies#S.C3.A9ralini_criticisms_of_toxicity_study_designs_and_responses|Genetically modified food controversies]] for details of this controversy, which extended beyond MON 863 to all GMOs.
In 2004 Monsanto sought approval in Europe to introduce MON 863, which led to controversy over acceptance by regulatory bodies of industry-funded toxicity studies and over the design of those studies. Pr Gilles Eric Séralini, who was on the committee that reviewed MON863 for the French government,<ref>[http://www.criigen.org/SiteEn/index.php?option=com_content&task=view&id=57&Itemid=105 Seralini bio on CRIIGEN]</ref> was a major figure in those controversies and continues to be a critic of toxicity study design.<ref>{{cite journal |doi=10.1016/j.fct.2012.08.005 |title=Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize |year=2012 |last1=Séralini |first1=Gilles-Eric |last2=Clair |first2=Emilie |last3=Mesnage |first3=Robin |last4=Gress |first4=Steeve |last5=Defarge |first5=Nicolas |last6=Malatesta |first6=Manuela |last7=Hennequin |first7=Didier |last8=De Vendômois |first8=Joël Spiroux |journal=Food and Chemical Toxicology |volume=50 |issue=11 |pages=4221}}</ref><ref>EFSA, 4 October 2012. [http://www.efsa.europa.eu/en/press/news/121004.htm Press release with summary of findings]. Full review: EFSA (2012) [http://www.efsa.europa.eu/en/efsajournal/doc/2910.pdf Review of the Séralini ''et al''. (2012) publication on a 2-year rodent feeding study with glyphosate formulations and GM maize NK603 as published online on 19 September 2012 in Food and Chemical Toxicology] EFSA Journal 2012;10(10):2910 doi=10.2903/j.efsa.2012.2910</ref>
 
Following legal action by parties including the [[Swedish Board of Agriculture]] and [[Greenpeace]], a [[Münster]] appeals court ruled that Monsanto would be forced to publicly reveal its research data.<ref name='Reilly 2010-01-23'>{{cite news | first = Michael | last = Reilly | title = Is Genetically Modified Corn Toxic? | date = 2010-01-23 | url = http://news.discovery.com/earth/is-genetically-modified-corn-toxic.html | work = Discovery News | accessdateaccess-date = 2010-07-21}}</ref>
 
See [[genetically_modified_food_controversies#S.C3.A9ralini_criticisms_of_toxicity_study_designs_and_responses|Genetically modified food controversies]] for details of this controversy, which extended beyond MON 863 to all GMOs.
 
Following legal action by parties including the [[Swedish Board of Agriculture]] and [[Greenpeace]], a [[Münster]] appeals court ruled that Monsanto would be forced to publicly reveal its research data.<ref name='Reilly 2010-01-23'>{{cite news | first = Michael | last = Reilly | title = Is Genetically Modified Corn Toxic? | date = 2010-01-23 | url = http://news.discovery.com/earth/is-genetically-modified-corn-toxic.html | work = Discovery News | accessdate = 2010-07-21}}</ref>
 
==Modified mechanisms==
MON 863 is genetically altered to express a modified version of [[Cry3Bb1]], a delta endotoxin which originates from ''[[Bacillus thuringiensis]]''.<ref name='Greenpeace MON863 chronicle'>{{cite web | url = http://www.greenpeace.org/international/Global/international/planet-2/report/2007/3/mon863_chronicle_of_deception.pdf | title = The MON863 case - a chronicle of systematic deception | accessdate = 2010-07-22 | format = PDF | publisher = [[Greenpeace]] | quote = MON863 is a genetically modified corn that expresses a Bt-toxin. This toxin is a modified version of the delta endotoxin Cry3Bb1 which originates from the microorganism Bacillus thuringiensis. The genetic manipulation is aimed at protecting maize plants against a pest called corn rootworm (Diabrotica spp.). MON863 differs from other Bt-corns already placed on the market (MON810, BT11, Bt176), which produce a modified Cry1Ab toxin conferring resistance to a pest called European corn borer (Ostrinia nubilalis), in that it produces an artificial Cry3Bb1 toxin. In addition to the modified Cry3Bb1 toxin gene MON863 contains an antibiotic resistance marker gene.}}</ref><ref name='Doull 2007 genetics'>{{cite journal |doi=10.1016/j.fct.2007.08.033 |title=Report of an Expert Panel on the reanalysis by of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863) |year=2007 |last1=Doull |first1=J. |last2=Gaylor |first2=D. |last3=Greim |first3=H.A. |last4=Lovell |first4=D.P. |last5=Lynch |first5=B. |last6=Munro |first6=I.C. |journal=Food and Chemical Toxicology |volume=45 |issue=11 |pages=2073–85 |pmid=17900781}}</ref> This protects the plant from [[Diabrotica|corn rootworm]].<ref name='Doull 2007 genetics' /><ref name='Coghlan 2010-01-22'>{{cite news | first = Andy | last = Coghlan | title = Engineered maize toxicity claims roundly rebuffed | date = 2010-01-22 | url = http://www.newscientist.com/article/mg20527444.000-engineered-maize-toxicity-claims-roundly-rebuffed.html | work = New Scientist | accessdate = 2010-07-21}}</ref> Unlike [[MON 810]], [[Bt 11]], and [[Bt 176]] which each produce a modified [[Cry1Ab]], MON 863 instead produces a modified Cry3Bb1 toxin and contains [[nptII]], a [[marker gene]] for [[antibiotic resistance]].<ref name='Greenpeace MON863 chronicle' /><ref name='Lorch 2005-09-30'>{{cite web | url = http://www.ifrik.org/files-ifrik/0509_greenpeace_mon863_hybrids.pdf | title = EFSA’s Opinion on MON863 hybrids | accessdate = 2010-07-22 | last = Lorch | first = Antje | date = 2005-09-30 | format = PDF | work = ifrik | publisher = [[Greenpeace]] | quote = MON863 contains an GM antibiotic resistance gene (nptII) against kanamycin and neomycin.}}</ref>
 
==Legal status==
As of 2015, MON 863 is approved for cultivation in three countries: the United States, Japan, and Canada. The corn is approved for use in [[Australia]], [[Canada]], [[China]], the [[European Union]], [[Japan]], [[Mexico]], [[New Zealand]], the [[Philippines]], [[Russia]], [[Singapore]], [[South Korea]], [[Taiwan]], and the [[United States]].<ref>Staff, name='MonsantoISAAA. safetyLast sheet'>{{citeupdated webJuly |27, url =2015 [http://www.monsantoisaaa.comorg/productsgmapprovaldatabase/techandsafetyevent/safetysummaries/focus863default.asp | title ?EventID= Technical 87& Safety Information - Focus on MON 863 / YieldGard Rootworm | accessdate Event=MON863 2010-07-22Event |Name: publisher = [[Monsanto]MON863] | quoteSee =Authorizations Based on these reviews, this maize has been authorized for planting in the United States and Canada since 2003 and is additionally approved for import and food use in many countries around the world, including Japan, Korea, Taiwan, the Philippines, Australia/New Zealand, China, Russia, Singapore, Mexico and the European Uniontab.}} {{Dead link|date=OctoberAccessed 2010|bot=H3llBot}}</ref><ref>StaffJune [http://dmedia.ucsc.edu/~bsharris/film%20170a/proj3/monsanto/monsanto/layout/products/technicalandsafety/MON863.html Focus on MON 863 / YieldGard® Rootworm] Monsanto Consume2, Technical And Safety Information, Accessed 5 April 20122016</ref>
 
==See also==
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==References==
{{reflist|2}}
 
 
{{corn}}{{Genetic engineering}}
{{Corn}}
{{corn}}{{Genetic engineering}}
 
{{DEFAULTSORT:Mon 863}}
[[Category:MaizeGenetically modified maize]]
[[Category:Genetically modified organisms in agricultureMonsanto]]
 
[[fr:MON 863]]

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