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* Eight transmembrane segments that form a channel and allow for copper to pass through the membrane;
* An ATP-binding domain;
* A large N-terminal cytosolic domain that contains six tandemly repeated copper-binding sites of about 30 amino acids, each containing a GMTCXXC motif.<ref name="5.Cellular multitasking: The dual role">{{cite journal|last1=Lutsenko|first1=Svetlana|last2=Gupta|first2=Arnab|last3=Burkhead|first3=Jason L.|last4=Zuzel|first4=Vesna|title=Cellular multitasking: The dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance|journal=Archives of Biochemistry and Biophysics|date=August 2008|volume=476|issue=1|pages=22–32|doi=10.1016/j.abb.2008.05.005}}</ref><ref name="1.Copper-related diseases: From chemistry">{{cite journal|last1=Crisponi|first1=Guido|last2=Nurchi|first2=Valeria Marina|last3=Fanni|first3=Daniela|last4=Gerosa|first4=Clara|last5=Nemolato|first5=Sonia|last6=Faa|first6=Gavino|title=Copper-related diseases: From chemistry to molecular pathology|journal=Coordination Chemistry Reviews|date=April 2010|volume=254|issue=7-8|pages=876–889|doi=10.1016/j.ccr.2009.12.018}}</ref><ref name="Textbook NEW">{{cite book|last1=Bertini|first1=Ivano|last2=Gray|first2=Harry|last3=Stiefel|first3=Edward|last4=Valentine|first4=Joan|title=Biological inorganic chemistry : structure and reactivity.|date=2006|publisher=University Science Books|location=Sausalito, CA|isbn=978-1-891389-43-6}}</ref><ref name=3.>{{cite journal|last1=Inesi|first1=Giuseppe|last2=Pilankatta|first2=Rajendra|last3=Tadini‑Buoninsegni|first3=Francesco|title=Biochemical characterization of P-type copper ATPases|journal=Biochemical Journal|date=15 October 2014|volume=463|issue=2|pages=167–176|doi=10.1042/BJ20140741}}</ref>
Many motifs in the ATP7A structure are conserved, such as the TGEA, CPC, DKTG, SEHPL, and GDGXND motifs. The TGEA motif lies in the loop on the cytosolic side between transmembrane segments 4 and 5 and is involved in energy transduction. The CPC motif located in transmembrane segment 6 is common for all heavy metal transporting ATPases. Between transmembrane segments 6 and 7 is a large cytoplasmic loop, where three motifs are located: DKTG, SEHPL, and GDGXND. The DKTG motif is essential for the proper function of the ATPase. The [[aspartic acid]] (D) residue is phosphorylated during the transport cycles. The SEHPL motif only exists in heavy metal transporting P-type ATPases. Without the [[histidine]] (H) residue ATP7A may not function properly. The GDGXND motif near transmembrane segment 7 is thought to contain mainly α-helices and serves as a structural support.<ref name="Textbook NEW" />
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