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File:Initiation of DNA demethylation at a CpG site.svg





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 File:Initiation of DNA demethylation at a CpG site.svg
Size of this PNG preview of this SVG file: 522 × 600 pixels. Other resolutions: 209 × 240 pixels | 418 × 480 pixels | 668 × 768 pixels | 891 × 1,024 pixels | 1,782 × 2,048 pixels | 643 × 739 pixels.

Original file ‎(SVG file, nominally 643 × 739 pixels, file size: 38 KB)





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English: Initiation of DNA demethylation at a CpG site. In adult somatic cells DNA methylation typically occurs in the context of CpG dinucleotides (CpG sites), forming 5-methylcytosine-pG, or 5mCpG. Reactive oxygen species (ROS) may attack guanine at the dinucleotide site, forming 8-hydroxy-2'-deoxyguanosine (8-OHdG), and resulting in a 5mCp-8-OHdG dinucleotide site. The base excision repair enzyme OGG1 targets 8-OHdG and binds to the lesion without immediate excision. OGG1, present at a 5mCp-8-OHdG site recruits TET1 and TET1 oxidizes the 5mC adjacent to the 8-OHdG. This initiates demethylation of 5mC.[1]
Date
Source Own work
Author Bernstein0275

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I, the copyright holder of this work, hereby publish it under the following license:
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    1. ↑ (September 2016). "OGG1 is essential in oxidative stress induced DNA demethylation". Cell. Signal. 28 (9): 1163–71. DOI:10.1016/j.cellsig.2016.05.021. PMID 27251462.

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    Initiation or DNA demethylation at a CpG site.

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    author name string: Bernstein0275
    Wikimedia username: Bernstein0275
    URL: http://commons.wikimedia.org/wiki/User:Bernstein0275

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    Creative Commons Attribution-ShareAlike 4.0 International

    15 December 2018

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    The following pages on the English Wikipedia use this file (pages on other projects are not listed):
    ●8-Oxo-2'-deoxyguanosine
    ●CpG site
    ●DNA damage (naturally occurring)
    ●DNA demethylation
    ●DNA oxidation
    ●DNA repair
    ●Epigenetics
    ●Epigenetics in learning and memory
    ●Reactive oxygen species
    ●Reprogramming
    ●TET enzymes
    ●User:L!ttleW0lf/Reprogramming

    Global file usage


    The following other wikis use this file:

    ●Usage on el.wikipedia.org

    ●Δραστικές μορφές οξυγόνου

    ●Usage on gl.wikipedia.org

    ●Sitio CpG

    ●Usage on nl.wikipedia.org

    ●TET-enzymen

    ●Usage on pt.wikipedia.org

    ●Sítio CpG

    ●Usage on uk.wikipedia.org

    ●Епігенетичне перепрограмування


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