Vixotrigine (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name), formerly known as raxatrigine (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name), is an analgesic which is under development by Convergence Pharmaceuticals for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia (TGN).[1][2][3] Vixotrigine was originally claimed to be a selective central Nav1.3 blocker, but was subsequently redefined as a selective peripheral Nav1.7 blocker.[citation needed] Following this, vixotrigine was redefined once again, as a non-selective voltage-gated sodium channel blocker.[citation needed] As of January 2018, it is in phase III clinical trials for trigeminal neuralgia and is in phase II clinical studies for erythromelalgia and neuropathic pain.[4] It was previously under investigation for the treatment of bipolar disorder, but development for this indication was discontinued.[4]
![]() | |
Clinical data | |
---|---|
Other names | Raxatrigine; CNV1014802; GSK-1014802; BIIB 074 |
Routes of administration | By mouth |
ATC code |
|
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C18H19FN2O2 |
Molar mass | 314.360 g·mol−1 |
3D model (JSmol) | |
| |
|
This analgesic-related article is a stub. You can help Wikipedia by expanding it. |