Contents

60S ribosomal protein L18a

Protein found in humans

RPL18A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL18A, L18A, ribosomal protein L18a
External IDs	OMIM: 604178; MGI: 1924058; HomoloGene: 68104; GeneCards: RPL18A; OMA:RPL18A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,859,910 bp[1] End 17,864,153 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 71,347,366 bp[2] End 71,350,056 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen left ovary granulocyte right ovary canal of the cervix right uterine tube lymph node left uterine tube spleen Top expressed in yolk sac ventricular zone spleen urinary bladder thymus embryo embryo ganglionic eminence lip adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding Cellular component cytosol ribosome membrane cytosolic large ribosomal subunit postsynaptic density polysomal ribosome synapse Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis response to antineoplastic agent cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6142 76808 Ensembl ENSG00000105640 ENSMUSG00000045128 UniProt Q02543 P62717 RefSeq (mRNA) NM_000980 NM_029751 RefSeq (protein) NP_000971 NP_084027 Location (UCSC) Chr 19: 17.86 – 17.86 Mb Chr 8: 71.35 – 71.35 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.^[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18AE family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U68 snoRNA, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

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