Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.[5]
This gene encodes the largest subunitofdynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD).[6] Dynactin binds to cytoplasmic dynein, dynein cargo adaptors, and microtubules.[7] It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
This subunit is commonly referred to p150-glued.[5] It is present in two copies per dynactin complex and forms an ≈75 nm long flexible arm that extends from the main body of dynactin.[6] The p150-glued arm contains binding sites for microtubules,[8] the microtubule plus tip binding protein EB1,[9] and the N-terminus of the dynein intermediate chain.[10][11]
Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.[12]
DCTN1 has been shown to interact with:
PDB gallery
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1txq: Crystal structure of the EB1 C-terminal domain complexed with the CAP-Gly domain of p150Glued
2coy: Solution structure of the CAP-Gly domain in human Dynactin 1
2hkn: Crystal structure of the CAP-Gly domain of human Dynactin-1 (p150-Glued)
2hkq: Crystal structure of the C-terminal domain of human EB1 in complex with the CAP-Gly domain of human Dynactin-1 (p150-Glued)
2hl3: Crystal structure of the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued) in complex with human EB1 C-terminal hexapeptide
2hl5: Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued)
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