Henderson was born in Montgomery, Alabama, and grew up in Selma, Alabama, where he attended John T. Morgan Academy and played basketball and baseball.[1] Henderson committed to play college baseball at Auburn University during his sophomore season.[2] As a senior in 2019, he was named the Alabama Player of the Year after batting .559 with 17 doubles, nine triples, 11 home runs, 69 runs scored and 75 RBIs while stealing 32 bases.[3] Henderson was also named the Alabama Independent School Association Player of the Year in basketball after averaging 17 points and 11 rebounds per game.[4][5] Two years after his graduation in 2019, his uniform number 2 was retired by the Morgan Academy baseball program on January 8, 2021.[6]
The Baltimore Orioles selected Henderson in the second round of the 2019 Major League Baseball draft with the 42nd overall pick.[7] Henderson signed with the club for a $2.3 million signing bonus.[8] After signing, he was assigned to the rookie-level Gulf Coast League Orioles.[9] Henderson finished his first professional season with a .259 batting average, one home run, and 11 RBI.[10]
After the 2020 minor league season was canceled due to the COVID-19 pandemic, Henderson was added to the Orioles' alternate training site midway through the Major League season and then took part in the team's fall Instructional League.[11][12] Henderson was named the best overall athlete in the Orioles' minor league system going into the 2021 season.[13] He began the season with the Low-ADelmarva Shorebirds and was promoted to the High-AAberdeen IronBirds and the Double-ABowie Baysox during the year.[14][15][16] Over 105 games between the three teams, he slashed .258/.350/.476 with 17 home runs, 74 RBI, 28 doubles and 16 stolen bases.[17]
Henderson began the 2022 season at Bowie.[18] He entered the season as a consensus top-100 prospect across baseball.[19] Henderson batted .312/.452/.573 in 157 at bats with eight home runs and 35 RBI with 41 runs scored in 47 games for the Baysox before being promoted to the Triple-ANorfolk Tides.[20] On June 28, 2022, the day before his 21st birthday, he hit for the cycle in a 8–2 win over the Gwinnett Stripers.[21] Henderson was selected to represent the Orioles at the 2022 All-Star Futures Game.[22]
The Orioles selected Henderson's contract on August 31, 2022, and promoted him to the active roster.[23] He made the starting roster later that day, in a game against the Cleveland Guardians. His first major league hit was a home run off of Triston McKenzie[24] Henderson batted .259 with four home runs and 18 RBIs in 34 games with the Orioles in 2022.[25] Following the season, Henderson was named the 2022 Baseball America Minor League Player of the Year. The honor came after Henderson hit .297 with 19 home runs, 76 RBI, and 22 stolen bases in 112 games split between Bowie and Norfolk.[26]
Henderson was awarded the March/April American League Player of the Month Award in recognition of his strong start to the 2024 season.[35] In 29 games, Henderson slashed .291/.356/.624 with 10 home runs, 24 RBI and six stolen bases.[36][37] A day after his 23rd birthday, Henderson announced that he will be taking part in the 2024 Home Run Derby[38] Henderson was selected to his first All-Star game in 2024 with his best friend Adley Rutschman joining in as Rutschman was selected to his second All-Star game, first as a starter. [39]
