| Monooxygenase | |||||||||
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Structure of the TetX monooxygenase in complex with the substrate 7-Iodtetracycline.[1]
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| Identifiers | |||||||||
| Symbol | FAD_binding_3 | ||||||||
| Pfam | PF01494 | ||||||||
| InterPro | IPR002938 | ||||||||
| SCOP2 | 2phh / SCOPe / SUPFAM | ||||||||
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Monooxygenases are enzymes that incorporate one hydroxyl group (−OH) into substrates in many metabolic pathways. In this reaction, the two atoms of dioxygen are reduced to one hydroxyl group and one H2O molecule by the concomitant oxidation of NAD(P)H.[2][3] One important subset of the monooxygenases, the cytochrome P450 omega hydroxylases, is used by cells to metabolize arachidonic acid (i.e. eicosatetraenoic acid) to the cell signaling molecules, 20-hydroxyeicosatetraenoic acid or to reduce or totally inactivate the activate signaling molecules for example by hydroxylating leukotriene B4 to 20-hydroxy-leukotriene B5, 5-hydroxyeicosatetraenoic acid to 5,20-dihydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid to 5-oxo-20-hydroxyeicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid to 12,20-dihydroxyeicosatetraenoic acid, and epoxyeicosatrienoic acids to 20-hydroxy-epoxyeicosatrienoic acids.
They are classified as oxidoreductase enzymes that catalyze an electron transfer.
COQ6; CYP450; MICAL1; MICAL2; MICAL2PV1; MICAL2PV2; MICAL3;
Media related to Monooxygenases at Wikimedia Commons|
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| 1.13.11: two atoms of oxygen |
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| 1.13.12: one atom of oxygen |
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| 1.13.99: other |
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| 1.14.11: 2-oxoglutarate |
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| 1.14.13: NADHorNADPH |
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| 1.14.14: reduced flavinorflavoprotein |
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| 1.14.15: reduced iron–sulfur protein |
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| 1.14.16: reduced pteridine (BH4 dependent) |
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| 1.14.17: reduced ascorbate |
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| 1.14.18-19: other |
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| 1.14.99 - miscellaneous |
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