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1 References  





2 Further reading  














RNR3: Difference between revisions






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{{Short description|Gene in the species Homo sapiens}}

<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->

{{Infobox_gene}}

{{PBB_Controls

'''RNA, ribosomal 3''', also known as '''RNR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNR3 RNA, ribosomal 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6054| accessdate = }}</ref> It is a minor [[Protein isoform|isoform]] of large subunit of [[Ribonucleoside-diphosphate reductase|ribonucleotide-diphosphate reductase]]; the [[RNP complex|RNR complex]] catalyzes the rate-limiting step in [[dNTP]] synthesis, regulated by [[DNA replication]] and [[DNA damage]] checkpoint pathways via localization of small subunits; RNR3 has a paralog, [[RNR1]], that arose from the whole [[genome duplication]].<ref>{{Cite web|url=https://www.yeastgenome.org/locus/RNR3|title = Rnr3 &#124; SGD}}</ref>

| update_page = yes

| require_manual_inspection = no

| update_protein_box = yes

| update_summary = yes

| update_citations = yes

}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{GNF_Protein_box

| image =

| image_source =

| PDB =

| Name = RNA, ribosomal 3

| HGNCid = 10084

| Symbol = RNR3

| AltSymbols =;

| OMIM = 180452

| ECnumber =

| Homologene =

| MGIid =

| Function =

| Component =

| Process =

| Orthologs = {{GNF_Ortholog_box

| Hs_EntrezGene = 6054

| Hs_Ensembl =

| Hs_RefseqProtein =

| Hs_RefseqmRNA =

| Hs_GenLoc_db =

| Hs_GenLoc_chr =

| Hs_GenLoc_start =

| Hs_GenLoc_end =

| Hs_Uniprot =

| Mm_EntrezGene =

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}}

'''RNA, ribosomal 3''', also known as '''RNR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNR3 RNA, ribosomal 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6054| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary

| section_title =

| summary_text =

}}



==References==

==References==

{{reflist}}

{{reflist}}


==Further reading==

==Further reading==

{{refbegin | 2}}

{{refbegin}}

* [[Nucleolus organizer region]]s are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22

{{PBB_Further_reading

*{{cite journal |vauthors=Kern SE, Kinzler KW, Bruskin A, etal |title=Identification of p53 as a sequence-specific DNA-binding protein. |journal=Science |volume=252 |issue= 5013 |pages= 1708–1711 |year= 1991 |pmid= 2047879 |doi=10.1126/science.2047879 |bibcode=1991Sci...252.1708K |s2cid=19647885 }}

| citations =

*{{cite journal | author=Kern SE, Kinzler KW, Bruskin A, ''et al.'' |title=Identification of p53 as a sequence-specific DNA-binding protein. |journal=Science |volume=252 |issue= 5013 |pages= 1708-11 |year= 1991 |pmid= 2047879 |doi= }}

*{{cite journal |vauthors=Gonzalez IL, Chambers C, Gorski JL, etal |title=Sequence and structure correlation of human ribosomal transcribed spacers. |journal=J. Mol. Biol. |volume=212 |issue= 1 |pages= 27–35 |year= 1990 |pmid= 2319598 |doi=10.1016/0022-2836(90)90302-3 |doi-access=free }}

*{{cite journal | author=Gonzalez IL, Chambers C, Gorski JL, ''et al.'' |title=Sequence and structure correlation of human ribosomal transcribed spacers. |journal=J. Mol. Biol. |volume=212 |issue= 1 |pages= 27-35 |year= 1990 |pmid= 2319598 |doi= }}

*{{cite journal | vauthors=Sylvester JE, Petersen R, Schmickel RD |title=Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter. |journal=Gene |volume=84 |issue= 1 |pages= 193–196 |year= 1990 |pmid= 2606358 |doi=10.1016/0378-1119(89)90155-8 }}

*{{cite journal | author=Sylvester JE, Petersen R, Schmickel RD |title=Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter. |journal=Gene |volume=84 |issue= 1 |pages= 193-6 |year= 1990 |pmid= 2606358 |doi= }}

*{{cite journal |vauthors=La Volpe A, Simeone A, D'Esposito M, etal |title=Molecular analysis of the heterogeneity region of the human ribosomal spacer. |journal=J. Mol. Biol. |volume=183 |issue= 2 |pages= 213–223 |year= 1985 |pmid= 2989541 |doi=10.1016/0022-2836(85)90214-1 }}

*{{cite journal | author=La Volpe A, Simeone A, D'Esposito M, ''et al.'' |title=Molecular analysisofthe heterogeneity region of the human ribosomal spacer. |journal=J. Mol. Biol. |volume=183 |issue= 2 |pages= 213-23 |year= 1985 |pmid= 2989541 |doi= }}

*{{cite journal | vauthors=Bartsch I, Schoneberg C, Grummt I |title=Evolutionary changesofsequences and factors that direct transcription termination of human and mouse ribsomal genes |journal=Mol. Cell. Biol. |volume=7 |issue= 7 |pages= 2521–2529 |year= 1987 |pmid= 3649563 |doi= 10.1128/mcb.7.7.2521| pmc=365386 }}

*{{cite journal | author=Bartsch I, Schoneberg C, Grummt I |title=Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes. |journal=Mol. Cell. Biol. |volume=7 |issue= 7 |pages= 2521-9 |year= 1987 |pmid= 3649563 |doi= }}

*{{cite journal | vauthors=Haltiner MM, Smale ST, Tjian R |title=Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 227–235 |year= 1987 |pmid= 3785147 |doi= 10.1128/mcb.6.1.227| pmc=367502 }}

*{{cite journal | author=Haltiner MM, Smale ST, Tjian R |title=Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis. |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 227-35 |year= 1987 |pmid= 3785147 |doi= }}

*{{cite journal |vauthors=Gonzalez IL, Gorski JL, Campen TJ, etal |title=Variation among human 28S ribosomal RNA genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 22 |pages= 7666–7670 |year= 1985 |pmid= 3865188 |doi=10.1073/pnas.82.22.7666 | pmc=391394 |bibcode=1985PNAS...82.7666G |doi-access=free }}

*{{cite journal | author=Gonzalez IL, Gorski JL, Campen TJ, ''et al.'' |title=Variation among human 28S ribosomal RNA genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 22 |pages= 7666-70 |year= 1985 |pmid= 3865188 |doi= }}

*{{cite journal | vauthors=McCallum FS, Maden BE |title=Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates |journal=Biochem.J. |volume=232 |issue= 3 |pages= 725–733 |year= 1986 |pmid= 4091818 |doi= 10.1042/bj2320725| pmc=1152944 }}

*{{cite journal | author=McCallum FS, Maden BE |title=Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates. |journal=Biochem. J. |volume=232 |issue= 3 |pages= 725-33 |year= 1986 |pmid= 4091818 |doi= }}

*{{cite journal | vauthors=Financsek I, Mizumoto K, Mishima Y, Muramatsu M |title=Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 10 |pages= 3092–3096 |year= 1982 |pmid= 6954460 |doi=10.1073/pnas.79.10.3092 | pmc=346359 |bibcode=1982PNAS...79.3092F |doi-access=free }}

*{{cite journal | author=Financsek I, Mizumoto K, Mishima Y, Muramatsu M |title=Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparisonofthree mammalian genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 10 |pages= 3092-6 |year= 1982 |pmid= 6954460 |doi= }}

*{{cite journal | vauthors=Gonzalez IL, Sylvester JE |title=Complete sequence of the 43-kb human ribosomal DNA repeat: analysisofthe intergenic spacer |journal=Genomics |volume=27 |issue= 2 |pages= 320–328 |year= 1995 |pmid= 7557999 |doi= 10.1006/geno.1995.1049 }}

*{{cite journal | author=Gonzalez IL, Sylvester JE |title=Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer. |journal=Genomics |volume=27 |issue= 2 |pages= 320-8 |year= 1995 |pmid= 7557999 |doi= 10.1006/geno.1995.1049 }}

*{{cite journal | vauthors=Gonzalez IL, Sylvester JE |title=Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes |journal=Genomics |volume=73 |issue= 3 |pages= 255–263 |year= 2001 |pmid= 11350117 |doi= 10.1006/geno.2001.6540 }}

*{{cite journal | author=Gonzalez IL, Sylvester JE |title=Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes. |journal=Genomics |volume=73 |issue= 3 |pages= 255-63 |year= 2001 |pmid= 11350117 |doi= 10.1006/geno.2001.6540 }}

}}

{{refend}}

{{refend}}



[[Category:Proteins]]

[[Category:Non-coding RNA]]

[[Category:RNA]]

[[Category:Ribosomal RNA]]

[[Category:Ribozymes]]

{{protein-stub}}

{{protein-stub}}


Latest revision as of 06:30, 6 February 2024

RNR3
Identifiers
AliasesRNR3, RNA, ribosomal 45S cluster 3
External IDsOMIM: 180452; GeneCards: RNR3; OMA:RNR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

RNA, ribosomal 3, also known as RNR3, is a human gene.[2] It is a minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes the rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication.[3]

References[edit]

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Entrez Gene: RNR3 RNA, ribosomal 3".
  • ^ "Rnr3 | SGD".
  • Further reading[edit]

    • Nucleolus organizer regions are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22
  • Kern SE, Kinzler KW, Bruskin A, et al. (1991). "Identification of p53 as a sequence-specific DNA-binding protein". Science. 252 (5013): 1708–1711. Bibcode:1991Sci...252.1708K. doi:10.1126/science.2047879. PMID 2047879. S2CID 19647885.
  • Gonzalez IL, Chambers C, Gorski JL, et al. (1990). "Sequence and structure correlation of human ribosomal transcribed spacers". J. Mol. Biol. 212 (1): 27–35. doi:10.1016/0022-2836(90)90302-3. PMID 2319598.
  • Sylvester JE, Petersen R, Schmickel RD (1990). "Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter". Gene. 84 (1): 193–196. doi:10.1016/0378-1119(89)90155-8. PMID 2606358.
  • La Volpe A, Simeone A, D'Esposito M, et al. (1985). "Molecular analysis of the heterogeneity region of the human ribosomal spacer". J. Mol. Biol. 183 (2): 213–223. doi:10.1016/0022-2836(85)90214-1. PMID 2989541.
  • Bartsch I, Schoneberg C, Grummt I (1987). "Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes". Mol. Cell. Biol. 7 (7): 2521–2529. doi:10.1128/mcb.7.7.2521. PMC 365386. PMID 3649563.
  • Haltiner MM, Smale ST, Tjian R (1987). "Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis". Mol. Cell. Biol. 6 (1): 227–235. doi:10.1128/mcb.6.1.227. PMC 367502. PMID 3785147.
  • Gonzalez IL, Gorski JL, Campen TJ, et al. (1985). "Variation among human 28S ribosomal RNA genes". Proc. Natl. Acad. Sci. U.S.A. 82 (22): 7666–7670. Bibcode:1985PNAS...82.7666G. doi:10.1073/pnas.82.22.7666. PMC 391394. PMID 3865188.
  • McCallum FS, Maden BE (1986). "Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates". Biochem. J. 232 (3): 725–733. doi:10.1042/bj2320725. PMC 1152944. PMID 4091818.
  • Financsek I, Mizumoto K, Mishima Y, Muramatsu M (1982). "Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes". Proc. Natl. Acad. Sci. U.S.A. 79 (10): 3092–3096. Bibcode:1982PNAS...79.3092F. doi:10.1073/pnas.79.10.3092. PMC 346359. PMID 6954460.
  • Gonzalez IL, Sylvester JE (1995). "Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer". Genomics. 27 (2): 320–328. doi:10.1006/geno.1995.1049. PMID 7557999.
  • Gonzalez IL, Sylvester JE (2001). "Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes". Genomics. 73 (3): 255–263. doi:10.1006/geno.2001.6540. PMID 11350117.
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