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{{Short description|Gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''RNA, ribosomal 3''', also known as '''RNR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNR3 RNA, ribosomal 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6054| accessdate = }}</ref> It is a minor [[Protein isoform|isoform]] of large subunit of [[Ribonucleoside-diphosphate reductase|ribonucleotide-diphosphate reductase]]; the [[RNP complex|RNR complex]] catalyzes the rate-limiting step in [[dNTP]] synthesis, regulated by [[DNA replication]] and [[DNA damage]] checkpoint pathways via localization of small subunits; RNR3 has a paralog, [[RNR1]], that arose from the whole [[genome duplication]].<ref>{{Cite web|url=https://www.yeastgenome.org/locus/RNR3|title = Rnr3 | SGD}}</ref> |
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{{GNF_Protein_box |
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| image = |
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| image_source = |
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| PDB = |
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| Name = RNA, ribosomal 3 |
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| HGNCid = 10084 |
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| Symbol = RNR3 |
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| AltSymbols =; |
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| OMIM = 180452 |
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| Homologene = |
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| Function = |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 6054 |
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| Hs_Ensembl = |
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| Hs_RefseqProtein = |
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| Hs_RefseqmRNA = |
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| Hs_GenLoc_db = |
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| Mm_EntrezGene = |
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| Mm_RefseqmRNA = |
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| Mm_RefseqProtein = |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = |
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}} |
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}} |
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'''RNA, ribosomal 3''', also known as '''RNR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNR3 RNA, ribosomal 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6054| accessdate = }}</ref> |
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==References== |
==References== |
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{{reflist}} |
{{reflist}} |
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==Further reading== |
==Further reading== |
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{{refbegin |
{{refbegin}} |
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* [[Nucleolus organizer region]]s are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22 |
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{{PBB_Further_reading |
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*{{cite journal |vauthors=Kern SE, Kinzler KW, Bruskin A, etal |title=Identification of p53 as a sequence-specific DNA-binding protein. |journal=Science |volume=252 |issue= 5013 |pages= 1708–1711 |year= 1991 |pmid= 2047879 |doi=10.1126/science.2047879 |bibcode=1991Sci...252.1708K |s2cid=19647885 }} |
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| citations = |
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*{{cite journal |
*{{cite journal |vauthors=Gonzalez IL, Chambers C, Gorski JL, etal |title=Sequence and structure correlation of human ribosomal transcribed spacers. |journal=J. Mol. Biol. |volume=212 |issue= 1 |pages= 27–35 |year= 1990 |pmid= 2319598 |doi=10.1016/0022-2836(90)90302-3 |doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Sylvester JE, Petersen R, Schmickel RD |title=Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter. |journal=Gene |volume=84 |issue= 1 |pages= 193–196 |year= 1990 |pmid= 2606358 |doi=10.1016/0378-1119(89)90155-8 }} |
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*{{cite journal |
*{{cite journal |vauthors=La Volpe A, Simeone A, D'Esposito M, etal |title=Molecular analysis of the heterogeneity region of the human ribosomal spacer. |journal=J. Mol. Biol. |volume=183 |issue= 2 |pages= 213–223 |year= 1985 |pmid= 2989541 |doi=10.1016/0022-2836(85)90214-1 }} |
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*{{cite journal | |
*{{cite journal | vauthors=Bartsch I, Schoneberg C, Grummt I |title=Evolutionary changesofsequences and factors that direct transcription termination of human and mouse ribsomal genes |journal=Mol. Cell. Biol. |volume=7 |issue= 7 |pages= 2521–2529 |year= 1987 |pmid= 3649563 |doi= 10.1128/mcb.7.7.2521| pmc=365386 }} |
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*{{cite journal | |
*{{cite journal | vauthors=Haltiner MM, Smale ST, Tjian R |title=Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis |journal=Mol. Cell. Biol. |volume=6 |issue= 1 |pages= 227–235 |year= 1987 |pmid= 3785147 |doi= 10.1128/mcb.6.1.227| pmc=367502 }} |
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*{{cite journal |
*{{cite journal |vauthors=Gonzalez IL, Gorski JL, Campen TJ, etal |title=Variation among human 28S ribosomal RNA genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 22 |pages= 7666–7670 |year= 1985 |pmid= 3865188 |doi=10.1073/pnas.82.22.7666 | pmc=391394 |bibcode=1985PNAS...82.7666G |doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=McCallum FS, Maden BE |title=Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates |journal=Biochem.J. |volume=232 |issue= 3 |pages= 725–733 |year= 1986 |pmid= 4091818 |doi= 10.1042/bj2320725| pmc=1152944 }} |
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*{{cite journal | |
*{{cite journal | vauthors=Financsek I, Mizumoto K, Mishima Y, Muramatsu M |title=Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 10 |pages= 3092–3096 |year= 1982 |pmid= 6954460 |doi=10.1073/pnas.79.10.3092 | pmc=346359 |bibcode=1982PNAS...79.3092F |doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Gonzalez IL, Sylvester JE |title=Complete sequence of the 43-kb human ribosomal DNA repeat: analysisofthe intergenic spacer |journal=Genomics |volume=27 |issue= 2 |pages= 320–328 |year= 1995 |pmid= 7557999 |doi= 10.1006/geno.1995.1049 }} |
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*{{cite journal | |
*{{cite journal | vauthors=Gonzalez IL, Sylvester JE |title=Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes |journal=Genomics |volume=73 |issue= 3 |pages= 255–263 |year= 2001 |pmid= 11350117 |doi= 10.1006/geno.2001.6540 }} |
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*{{cite journal | author=Gonzalez IL, Sylvester JE |title=Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes. |journal=Genomics |volume=73 |issue= 3 |pages= 255-63 |year= 2001 |pmid= 11350117 |doi= 10.1006/geno.2001.6540 }} |
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}} |
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{{refend}} |
{{refend}} |
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[[Category:Proteins]] |
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[[Category:Non-coding RNA]] |
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[[Category:RNA]] |
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[[Category:Ribosomal RNA]] |
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[[Category:Ribozymes]] |
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{{protein-stub}} |
{{protein-stub}} |
RNR3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | RNR3, RNA, ribosomal 45S cluster 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 180452; GeneCards: RNR3; OMA:RNR3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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RNA, ribosomal 3, also known as RNR3, is a human gene.[2] It is a minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes the rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication.[3]
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