The wing has four primary missions. It supports aeromedical evacuation within the United States. It provides operational support airlift for government officials. It offers direct security for U.S. community and nation. And it provides support for U.S. host units—making possible the command and control of the United States' entire military transportation effort.
The 375 Troop Carrier Wing, Medium was activated at Greater Pittsburgh Airport, Pennsylvania and trained in the Reserve from May 1949 until it was called to active duty in October 1950. After a period of intensive training, now as a wing, it participated in troop carrier and airlift operations, paratroop drops, and other exercises, October 1950 – July 1952.
Between January 1966 and April 1975 the wing maintained and scheduled support aircraft at Scott Air Force Base, Illinois, generally using aircrews provided by other Scott-based units to provide scheduled air shuttle and courier service to the east and west coasts. From January 1966 to September 1968 and since June 1973, the wing operated and maintained Scott AFB.
It airlifted more than 700 VA hospital patients from Biloxi and Gulfport, Mississippi, to safety during Hurricane Camille in August 1969; during Project Homecoming in early 1973 the wing flew 119 sorties to airlift some 350 U.S. prisoners of war to 26 hospitals in the United States. In October 1973, it served as an aeromedical evacuation center established under wing control at Scott Air Force Base, Illinois, assumed the functions previously handled by smaller centers at Scott, McGuire Air Force Base, New Jersey, and Travis Air Force Base, California. In April 1975, when the aeromedical evacuation support units in Germany and the Far East came under the wing's control, it became the single-point manager for worldwide DoD aeromedical evacuation services. It evacuated wounded during the invasionofGrenada, 24 October – 9 November 1983. It transported 350 wounded Afghan citizens to hospitals in the United States, May–December 1987. It controlled the 1467th Facility Checking Squadron from October 1987 – September 1991, which inspected DoD navigation aids and radar facilities worldwide. The wing operated and maintained an aeromedical evacuation system on a rotational basis in Southwest Asia, September 1990 – April 1991. It deployed an aeromedical evacuation element to support Operation Allied Force in 1999.
Finneran, John P., and Sam J. Commell (eds.). The History of the Tokyo Trolley: 375th Troop Carrier Group, June 1942 – January 1946. Tokyo: Dai Nippon Printing Company, 1946.