ATP6AP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | ATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2R | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300556; MGI: 1917745; HomoloGene: 38097; GeneCards: ATP6AP2; OMA:ATP6AP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[5][6][7]
The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogentoangiotensin I.[8]
This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[7]
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