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( R e d i r e c t e d f r o m B e n i g n o r t h o s t a t i c ( p o s t u r a l ) p r o t e i n u r i a )
Orthostatic albuminuria , also known as orthostatic proteinuria is defined by raised levels of urine protein excretion while in an upright position. In orthostatic albuminuria urine protein excretion returns to normal while in a supine position, such as laying down. Orthostatic albuminuria is the most common cause of isolated proteinuria in those under 20.[5] [6] [7] albuminuria .[8] [4]
The exact causes of orthostatic albuminuria are unknown however three different theories have been proposed, a normal variant, subtle glomerular abnormalities, exaggerated hemodynamic response, and left renal vein entrapment .[9]
Diagnosis [ edit ]
There is no standard test for orthostatic albuminuria. Physical examination as well as a past medical history can help determine the extent of symptoms in some individuals. Urine analysis , urine cytology , complement activity, urine culture , and serological studies can help differentiate orthostatic albuminuria from other causes of proteinuria . Recumbent and upright urine protein to creatinine ratio is often used as a screening test. 24-hour split urine testing is often tested.[10]
Additional causes of albuminuria include glomerulopathy , acute tubular necrosis , Alport syndrome , toxins , proximal renal tubular acidosis , diabetes mellitus , malignancies , polycystic kidney disease , infections , and chronic kidney disease .[8]
Outlook [ edit ]
The long-term prognosis of orthostatic albuminuria hasn't yet been established. Based on current research, it seems that orthostatic albuminuria is a benign condition and typically resolves spontaneously within a couple years.[11]
See also [ edit ]
References [ edit ]
^ "albuminuria" . Oxford English Dictionary . Oxford University Press. July 2023. Retrieved 24 November 2023 .
^ a b c d Moses, Scott (February 17, 2017). "Orthostatic Proteinuria" . Family Practice Notebook . Retrieved November 24, 2023 .
^ a b "UpToDate" . UpToDate . Retrieved November 24, 2023 .
^ Uehara, K.; Tominaga, N.; Shibagaki, Y. (May 25, 2014). "Adult orthostatic proteinuria" . Clinical Kidney Journal . 7 3 ): 327–328. doi :10.1093/ckj/sfu040 ISSN 2048-8505 . PMC 4377758 PMID 25852903 .
^ Mazzoni, M. B. M.; Kottanatu, L.; Simonetti, G. D.; Ragazzi, M.; Bianchetti, M. G.; Fossali, E. F.; Milani, G. P. (July 23, 2010). "Renal vein obstruction and orthostatic proteinuria: a review" . Nephrology Dialysis Transplantation . 26 2 ): 562–565. doi :10.1093/ndt/gfq444 ISSN 0931-0509 . PMID 20656752 . Retrieved November 24, 2023 .
^ Vehaskari, V. Matti; Rapola, Juhani (1982). "Isolated proteinuria: Analysis of a school-age population" . The Journal of Pediatrics . 101 (5 ): 661–668. doi :10.1016/s0022-3476(82 )80287-4 . ISSN 0022-3476 . PMID 7131137 . Retrieved November 24, 2023 .
^ a b AK, Leung; AH, Wong; SS, Barg (2017). "Proteinuria in Children: Evaluation and Differential Diagnosis" . American Family Physician . 95 4 ): 248–254. ISSN 1532-0650 . PMID 28290633 . Retrieved November 24, 2023 .
^ Ingold, Curtis J.; Bhatt, Harshil (August 8, 2023). "Orthostatic Proteinuria" . StatPearls Publishing. PMID 32965979 . Retrieved November 24, 2023 .
^ Kovvuru, Karthik; Kanduri, Swetha R.; Thongprayoon, Charat; Cheungpasitporn, Wisit (2020). "Diagnostic approach to orthostatic proteinuria: a combination of urine micro-proteinuria with ultrasonography of the left renal vein" . Annals of Translational Medicine . 8 12 ): 779. doi :10.21037/atm.2020.02.50 ISSN 2305-5839 . PMC 7333150 PMID 32647704 .
^ Arslan, Zümrüt; Koyun, Mustafa; Erengin, Hakan; Akbaş, Halide; Aksoy, Gülşah Kaya; Çomak, Elif; Akman, Sema (May 11, 2020). "Orthostatic proteinuria: an overestimated phenomenon?" . Pediatric Nephrology . 35 10 ): 1935–1940. doi :10.1007/s00467-020-04586-4 . ISSN 0931-041X . PMID 32394189 . S2CID 218592496 . Retrieved November 24, 2023 .
Further reading [ edit ]
Vehaskari, V M (October 1, 1982). "Orthostatic proteinuria" . Archives of Disease in Childhood . 57 10 ): 729–730. doi :10.1136/adc.57.10.729 ISSN 0003-9888 . PMC 1627924 PMID 7138061 .
von Bonsdorff, Martin; Törnroth, Tom; Pasternack, Amos (1982). "Renal Biopsy Findings in Orthostatic Proteinuria" . Acta Pathologica Microbiologica Scandinavica Series A: Pathology . 90A (1–6): 11–18. doi :10.1111/j.1699-0463.1982.tb00058_90a.x . ISSN 0108-0164 . PMID 7080809 . Retrieved November 24, 2023 .
Brandt, John Robert; Jacobs, Aaron; Raissy, Hengameh H.; Kelly, Franceska Marie; Staples, Amy Otten; Kaufman, Ellen; Wong, Craig Stephen (February 18, 2010). "Orthostatic proteinuria and the spectrum of diurnal variability of urinary protein excretion in healthy children" . Pediatric Nephrology . 25 6 ): 1131–1137. doi :10.1007/s00467-010-1451-z . ISSN 0931-041X . PMC 3677044 PMID 20165888 .
Vehaskari, V. Matti (1990). "Mechanism of orthostatic proteinuria" . Pediatric Nephrology . 4 4 ): 328–330. doi :10.1007/bf00862510 . ISSN 0931-041X . PMID 2206899 . S2CID 26930865 . Retrieved November 24, 2023 .
Sebestyen, Judith F.; Alon, Uri S. (September 13, 2010). "The Teenager With Asymptomatic Proteinuria: Think Orthostatic First" . Clinical Pediatrics . 50 3 ): 179–182. doi :10.1177/0009922810380904 . ISSN 0009-9228 . PMID 20837623 . S2CID 8219563 . Retrieved November 24, 2023 .
External links [ edit ]
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Orthostatic_albuminuria&oldid=1231018927 " C a t e g o r y : ● K i d n e y d i s e a s e s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a
● T h i s p a g e w a s l a s t e d i t e d o n 2 6 J u n e 2 0 2 4 , a t 0 0 : 2 9 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
