chemokine (C-C motif) ligand 27 | |||||||
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Identifiers | |||||||
Symbol | CCL27 | ||||||
Alt. symbols | SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK | ||||||
NCBI gene | 10850 | ||||||
HGNC | 10626 | ||||||
OMIM | 604833 | ||||||
RefSeq | NM_006664 | ||||||
UniProt | Q9Y4X3 | ||||||
Other data | |||||||
Locus | Chr. 9 q13 | ||||||
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C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [5]
This gene is one of several CC cytokine genes clustered on the p-armofchromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[6][7] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[8] The gene for CCL27 is located on human chromosome 9.[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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