Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.[5]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[6]
EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal modelofAlzheimer's disease.[7]
Arecessive EphB2 gene is responsible for the crested-feather mutation in pigeons.[8]
EPH receptor B2 has been shown to interact with:
PDB gallery
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1b4f: OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN
1f0m: MONOMERIC STRUCTURE OF THE HUMAN EPHB2 SAM (STERILE ALPHA MOTIF) DOMAIN
1jpa: Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region
1kgy: Crystal Structure of the EphB2-ephrinB2 complex
1nuk: CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE
1sgg: THE SOLUTION STRUCTURE OF SAM DOMAIN FROM THE RECEPTOR TYROSINE KINASE EPHB2, NMR, 10 STRUCTURES
1shw: EphB2 / EphrinA5 Complex Structure
2hen: Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP
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PDGF |
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TGFβ |
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Trk |
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VEGF |
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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