Names | |
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IUPAC name
2-(Acetylamino)-2-deoxy-D-galactose | |
Other names
GalNAc; 2-Acetamido-2-deoxy-D-galactose; N-Acetylchondrosamine; 2-Acetamido-2-deoxy-D-galactopyranose; N-Acetyl-D-galactosamine | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChemSpider |
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DrugBank | |
KEGG |
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PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C8H15NO6 | |
Molar mass | 221.21 g/mol |
Melting point | 172 to 173 °C (342 to 343 °F; 445 to 446 K) |
Related compounds | |
Related monosaccharides |
N-Acetylglucosamine Galactosamine Galactose |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose.
In humans it is the terminal carbohydrate forming the antigen of blood group A.[1]
It is typically the first monosaccharide that connects serineorthreonine in particular forms of protein O-glycosylation.
N-Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals.
GalNAc is also used as a targeting ligand in investigational antisense oligonucleotides and siRNA therapies targeted to the liver, where it binds to the asialoglycoprotein receptorsonhepatocytes. [2]