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Contents

   



(Top)
  


1 Function  




2 Clinical significance  




3 Interactions  




4 References  




5 Further reading  













RP9






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From Wikipedia, the free encyclopedia
  
(Redirected from PAP1)
RP9
Identifiers
AliasesRP9, PAP-1, PAP1, retinitis pigmentosa 9 (autosomal dominant), pre-mRNA splicing factor, RP9 pre-mRNA splicing factor
External IDsOMIM: 607331; MGI: 2157166; HomoloGene: 10290; GeneCards: RP9; OMA:RP9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6100

55934

Ensembl

ENSG00000164610

ENSMUSG00000032239

UniProt

Q8TA86

P97762

RefSeq (mRNA)

NM_203288

NM_018739

RefSeq (protein)

NP_976033

NP_061209

Location (UCSC)Chr 7: 33.09 – 33.11 MbChr 9: 22.32 – 22.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinitis pigmentosa 9 (autosomal dominant), also known as RP9orPAP-1, is a protein which in humans is encoded by the RP9 gene.[5]

Function

[edit]

The removal of introns from nuclear pre-mRNAs occurs on a complex called a spliceosome, which is made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. The exact role of PAP-1 in splicing is not fully understood, but it is thought that PAP-1 localizes in nuclear speckles containing the splicing factor SC35 and interacts directly with another splicing factor, U2AF35.[6]

Clinical significance

[edit]

Mutations in PAP1 underlie autosomal dominant retinitis pigmentosa mapped to the RP9 gene locus.[7]

Interactions

[edit]

RP9 has been shown to interact with U2 small nuclear RNA auxiliary factor 1.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164610 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032239 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Entrez Gene: RP9 retinitis pigmentosa 9 (autosomal dominant)".
  • ^ a b Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SM (November 2004). "PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor". Exp. Cell Res. 300 (2): 283–96. doi:10.1016/j.yexcr.2004.07.029. PMID 15474994.
  • ^ Keen TJ, Hims MM, McKie AB, Moore AT, Doran RM, Mackey DA, Mansfield DC, Mueller RF, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF (April 2002). "Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa". Eur. J. Hum. Genet. 10 (4): 245–9. doi:10.1038/sj.ejhg.5200797. PMID 12032732.

    • Further reading

    [edit]
  • Inglehearn CF, Carter SA, Keen TJ, et al. (1993). "A new locus for autosomal dominant retinitis pigmentosa on chromosome 7p". Nat. Genet. 4 (1): 51–3. doi:10.1038/ng0593-51. PMID 8513323. S2CID 33087284.
  • Maita H, Harada Y, Nagakubo D, et al. (2000). "PAP-1, a novel target protein of phosphorylation by pim-1 kinase". Eur. J. Biochem. 267 (16): 5168–78. doi:10.1046/j.1432-1327.2000.01585.x. PMID 10931201.
  • Keen TJ, Hims MM, McKie AB, et al. (2002). "Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa". Eur. J. Hum. Genet. 10 (4): 245–9. doi:10.1038/sj.ejhg.5200797. PMID 12032732.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Maita H, Kitaura H, Keen TJ, et al. (2004). "PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor". Exp. Cell Res. 300 (2): 283–96. doi:10.1016/j.yexcr.2004.07.029. PMID 15474994.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (2005). "Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex". Exp. Cell Res. 302 (1): 61–8. doi:10.1016/j.yexcr.2004.08.022. PMID 15541726.
  • Kuroda TS, Maita H, Tabata T, et al. (2004). "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase". Gene. 340 (1): 83–98. doi:10.1016/j.gene.2004.05.025. PMID 15556297.
  • Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Exp. Cell Res. 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.


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