Contents

PPP1R12A

Protein-coding gene in the species Homo sapiens

PPP1R12A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KJY, 2MXR, 5HUZ
Identifiers
Aliases	PPP1R12A, M130, MBS, MYPT1, protein phosphatase 1 regulatory subunit 12A, GUBS
External IDs	OMIM: 602021; MGI: 1309528; HomoloGene: 1855; GeneCards: PPP1R12A; OMA:PPP1R12A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.2-q21.31 Start 79,773,563 bp[1] End 79,935,460 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D1|10 56.33 cM Start 107,998,054 bp[2] End 108,120,336 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve saphenous vein tail of epididymis epithelium of colon popliteal artery tibial arteries urethra right coronary artery vena cava Top expressed in ascending aorta aortic valve conjunctival fornix zygote secondary oocyte iris otolith organ primary oocyte utricle hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity 14-3-3 protein binding signal transducer activity protein binding protein kinase binding phosphatase regulator activity Cellular component centrosome focal adhesion nucleoplasm Z disc PTW/PP1 phosphatase complex actin cytoskeleton contractile fiber A band kinetochore cytoplasm cytosol cytoskeleton Biological process regulation of nucleocytoplasmic transport positive regulation of myosin-light-chain-phosphatase activity negative regulation of catalytic activity regulation of cell adhesion G2/M transition of mitotic cell cycle regulation of myosin-light-chain-phosphatase activity regulation of establishment of endothelial barrier positive regulation of transcription by RNA polymerase II signal transduction protein dephosphorylation mitotic cell cycle centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4659 17931 Ensembl ENSG00000058272 ENSMUSG00000019907 UniProt O14974 Q9DBR7 RefSeq (mRNA) NM_001143885 NM_001143886 NM_001244990 NM_001244992 NM_002480 NM_027892 NM_001368736 NM_001368737 RefSeq (protein) NP_001137357 NP_001137358 NP_001231919 NP_001231921 NP_002471 NP_082168 NP_001355665 NP_001355666 Location (UCSC) Chr 12: 79.77 – 79.94 Mb Chr 10: 108 – 108.12 Mb PubMed search [3] [4]
Wikidata
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Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.^[5][6]

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle ^[7] and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.^[6]

Interactions[edit]

PPP1R12A has been shown to interact with Interleukin 16.^[8]

References[edit]

Further reading[edit]

External links[edit]

• PPP1R12A Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.