Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.[5][6]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.[6]
PDB gallery
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1q1q: Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP
1q1z: Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP
1q20: Crystal Structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP and pregnenolone
1q22: Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP
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