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1 See also  




2 References  













Nedocromil






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From Wikipedia, the free encyclopedia
  
(Redirected from Tilade)
Nedocromil
Structural formula of nedocromil
Space-filling model of the nedocromil molecule
Clinical data
Trade namesAlocril
AHFS/Drugs.comMonograph
MedlinePlusa601243
Routes of
administration		Inhalation and eye drops
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
    • Pharmacokinetic data
    Protein binding89%
    Metabolismnot metabolized
    Elimination half-life~3.3 hours
    Excretionexcreted unchanged
    Identifiers

    • 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid

    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.233.208 Edit this at Wikidata
    Chemical and physical data
    FormulaC19H17NO7
    Molar mass371.345 g·mol−1
    3D model (JSmol)

    • O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC

    • InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) checkY

    • Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N checkY

      (verify)

    Nedocromil sodium is a medication considered as mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade, and as an eye drop under the brand name Alocril.[1][2] The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators like albuterol or other well-known inhaler medications. Liquid preparations of nedocromil are available in the UK under the name Rapitil for use for allergic eye reactions.[3] Nedocromil sodium has been shown to be effective in alleviating symptoms of allergic conjunctivitis.[4]

    Nedocromil is classified as a benzopyrone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008 because it used CFCs as propellant.[5]

    See also[edit]

    References[edit]

    Media related to Nedocromil at Wikimedia Commons

    1. ^ "ALOCRIL Product Information". Allergan. Archived from the original on 8 May 2013. Retrieved 17 May 2013.
  • ^ Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Retrieved 17 May 2013.
  • ^ "Nedocromil eye drops". Patient.info. 2007-02-02. Retrieved 2009-08-04.
  • ^ Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis" (PDF). The Cochrane Database of Systematic Reviews. 6 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMID 26028608.
  • ^ "Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil". U.S. Food and Drug Administration. 13 April 2010. Archived from the original on 2 February 2012.
    • Stub icon

    This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

  • t
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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Nedocromil&oldid=1178755347"
    Categories: 
    ●Mast cell stabilizers
     ●Ophthalmology drugs
     ●Dicarboxylic acids
     ●Nitrogen heterocycles
     ●Oxygen heterocycles
     ●Heterocyclic compounds with 3 rings
     ●Diketones
     ●Respiratory system drug stubs
     Hidden categories: 
    ●Articles with short description
     ●Short description matches Wikidata
     ●ECHA InfoCard ID from Wikidata
     ●Commons category link from Wikidata
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