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VK2809

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VK2809
Clinical data

Other names	VK-2809; MB07811
Identifiers
IUPAC name (2R,4S)-4-(3-Chlorophenyl)-2-[(4-{[4-hydroxy-3-(propan-2-yl)phenyl]methyl}-3,5-dimethylphenoxy)methyl]-1,3,2λ⁵-dioxaphosphinan-2-one
CAS Number	852948-13-1
DrugBank	DB15137
UNII	3Z11398FNQ
CompTox Dashboard (EPA)	DTXSID501005783
Chemical and physical data
Formula	C₂₈H₃₂ClO₅P
Molar mass	514.98 g·mol⁻¹

VK2809 (formerly known as MB07811) is a thyromimetic prodrug whose active form is selective for the THR-β isoform. It is being developed by Viking Therapeutics in a phase II trial for the treatment of nonalcoholic steatohepatitis^[1]^[2] and is also being investigated for glycogen storage disease type Ia.^[3]

References[edit]

^ Zhou, Jin; Waskowicz, Lauren R.; Lim, Andrea; Liao, Xiao-Hui; Lian, Brian; Masamune, Hiroko; Refetoff, Samuel; Tran, Brian; Koeberl, Dwight D.; Yen, Paul M. (1 August 2019). "A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia". Thyroid. 29 (8): 1158–1167. doi:10.1089/thy.2019.0007. ISSN 1050-7256. PMC 6707038. PMID 31337282.