Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion
Hum Exp Toxicol. 2006 Feb;25(2):99-105.
doi: 10.1191/0960327106ht594oa.
Authors
P Guzelian 1, L Quattrochi, N Karch, L Aylward, R Kaley
Affiliation
●1University of Colorado Health Science Center, Box B-146, 4200 East 9th Avenue, BRB 723, Denver, CO 80262, USA.
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PMID:
16539215
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DOI:
10.1191/0960327106ht594oa
Abstract
Evidence-based toxicology like evidence-based medicine, provides scientifically grounded evidence-based conclusions as distinguished from authority-based opinions. As an example, we address a proposition from the US Environmental Protection Agency's (EPA) Draft Dioxin [2,3, 7,8-tetrachlorodibenzo-P-dioxin (TCDD)] reassessment that: 'dioxin...can produce effects...at or near current background body burdens or intake levels'. Guided by a systematic, objective, and unbiased analysis of the available molecular, physiological, and clinical/epidemiologic data, in accordance with accepted principles of scientific logic, we reach the evidence-based conclusion that the proposition is rejected. When gaps in scientific knowledge necessitate formulation of opinions to meet preventive or precautionary goals, the reversion to authority should be explicitly acknowledged.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Body Burden
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Dioxins / toxicity*
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Dose-Response Relationship, Drug
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Environmental Pollutants / toxicity*
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Evidence-Based Medicine
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Humans
Substances
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Dioxins
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Environmental Pollutants
Grants and funding
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GM54477/GM/NIGMS NIH HHS/United States