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ADAM18

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Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.^[5]^[6]

ADAM18

Identifiers

ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18

External IDs

MGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p11.22	Start	39,584,489 bp^[1]
Band	8p11.22	End	39,730,065 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 A2	Start	25,092,262 bp^[2]
Band	8\|8 A2	End	25,164,771 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

left testis

right testis

testicle

gonad

monocyte

right coronary artery

apex of heart

left ventricle

urinary bladder

Top expressed in

spermatocyte

spermatid

seminiferous tubule

visual cortex

primary visual cortex

superior frontal gyrus

islet of Langerhans

somite

More reference expression data


More reference expression data

Gene ontology
Molecular function	metalloendopeptidase activity metallopeptidase activity
Cellular component	integral component of membrane membrane
Biological process	multicellular organism development cell differentiation spermatogenesis proteolysis
Sources:Amigo / QuickGO

Species

Human

Mouse


8749


13524


ENSG00000168619 ENSG00000278548


ENSMUSG00000031552


Q9Y3Q7


Q9R157

RefSeq (mRNA)


NM_001190956 NM_014237 NM_001320313


NM_010084

RefSeq (protein)


NP_001177885 NP_001307242 NP_055052


NP_034214

Location (UCSC)

Chr 8: 39.58 – 39.73 Mb

Chr 8: 25.09 – 25.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.^[6]

References

^ ^a ^b ^c ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031552 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.

^ ^a ^b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". Gene. 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.

Frayne J, Jury JA, Barker HL, et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.

Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

The MEROPS online database for peptidases and their inhibitors: M12.957
Human ADAM18 genome location and ADAM18 gene details page in the UCSC Genome Browser.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=ADAM18&oldid=1166576811" Last edited on 22 July 2023, at 13:22

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