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Bombesin-like receptor 3





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The bombesin receptor subtype 3 also known as BRS-3orBB3[5] is a protein which in humans is encoded by the BRS3 gene.[6][7]

BRS3
Identifiers
AliasesBRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3, BBR3
External IDsOMIM: 300107; MGI: 1100501; HomoloGene: 1307; GeneCards: BRS3; OMA:BRS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

680

12209

Ensembl

ENSG00000102239

ENSMUSG00000031130

UniProt

P32247

O54798

RefSeq (mRNA)

NM_001727

NM_009766

RefSeq (protein)

NP_001718

NP_033896

Location (UCSC)Chr X: 136.49 – 136.49 MbChr X: 56.09 – 56.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]

BB3 is a G protein-coupled receptor.[6]BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[6][9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102239 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031130 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
  • ^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. doi:10.1016/S0021-9258(18)53415-3. PMID 8383682.
  • ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170. S2CID 1012779.
  • ^ "Entrez Gene: BRS3 bombesin-like receptor 3".
  • ^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.
  • ^ Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

    • Further reading

    edit
  • Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. doi:10.1016/S0021-9258(18)53415-3. PMID 8383682.
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. S2CID 30893871.
  • Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity". Nature. 390 (6656): 165–9. Bibcode:1997Natur.390..165O. doi:10.1038/36568. PMID 9367152. S2CID 4400418.
  • Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3". J. Biol. Chem. 273 (22): 13613–24. doi:10.1074/jbc.273.22.13613. PMID 9593699.
  • Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)". Biochemistry. 41 (28): 8954–60. doi:10.1021/bi0202777. PMID 12102638.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells". Lung Cancer. 54 (2): 143–8. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.
  • Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells". Biochem. J. 405 (1): 131–7. doi:10.1042/BJ20061754. PMC 1925247. PMID 17355223.
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    Last edited on 19 October 2023, at 10:15  





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