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Epigen

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Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.^[5]^[6]

EPGN

Identifiers

EPGN, ALGV3072, EPG, PRO9904, epithelial mitogen

External IDs

MGI: 1919170; HomoloGene: 19527; GeneCards: EPGN; OMA:EPGN - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.3	Start	74,308,470 bp^[1]
Band	4q13.3	End	74,316,789 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 E1	Start	91,175,323 bp^[2]
Band	5\|5 E1	End	91,183,074 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of esophagus

vagina

skin of leg

appendix

skin of abdomen

right lung

tonsil

bone marrow cells

ectocervix

mucosa of transverse colon

Top expressed in

embryo

cornea

embryo

hair follicle

spermatid

lip

skin of abdomen

conjunctival fornix

skin of back

muscle of thigh

More reference expression data

n/a

Gene ontology
Molecular function	epidermal growth factor receptor binding growth factor activity
Cellular component	integral component of membrane extracellular region integral component of plasma membrane intracellular anatomical structure membrane extracellular space clathrin-coated vesicle membrane
Biological process	positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of MAP kinase activity angiogenesis positive regulation of cell population proliferation MAPK cascade positive regulation of epithelial cell proliferation epidermal growth factor receptor signaling pathway signal transduction negative regulation of epidermal growth factor receptor signaling pathway positive regulation of protein kinase B signaling membrane organization
Sources:Amigo / QuickGO

Species

Human

Mouse


255324


71920


ENSG00000182585


ENSMUSG00000035020


Q6UW88


Q924X1

RefSeq (mRNA)

NM_001013442 NM_001270989 NM_001270990 NM_001270991 NM_001270992
NM_001270993


NM_053087

RefSeq (protein)


NP_001257918 NP_001257919 NP_001257920 NP_001257921 NP_001257922


NP_444317

Location (UCSC)

Chr 4: 74.31 – 74.32 Mb

Chr 5: 91.18 – 91.18 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182585 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035020 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b "Entrez Gene: Epithelial mitogen".

^ Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

External links

epigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Epigen&oldid=1118645305" Last edited on 28 October 2022, at 03:36

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