● Home ● Random ● Nearby ● Log in ● Settings ● Donate ● About Wikipedia ● Disclaimers

Frizzled-8

● Article ● Talk ● Language ● Watch ● Edit

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.^[5]^[6]

FZD8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1IJY, 4F0A

Identifiers

FZD8, FZ-8, hFZ8, frizzled class receptor 8

External IDs

OMIM: 606146; MGI: 108460; HomoloGene: 40606; GeneCards: FZD8; OMA:FZD8 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p11.21	Start	35,638,247 bp^[1]
Band	10p11.21	End	35,642,296 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18 A1\|18 4.91 cM	Start	9,212,163 bp^[2]
Band	18 A1\|18 4.91 cM	End	9,218,136 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

cartilage tissue

ganglionic eminence

retinal pigment epithelium

tendon of biceps brachii

trabecular bone

lactiferous duct

pancreatic epithelial cell

pancreatic ductal cell

spinal ganglia

Top expressed in

ventricular zone

hypoblast

calvaria

retinal pigment epithelium

left lobe of liver

ankle

ciliary body

molar

primitive endoderm

trigeminal ganglion

More reference expression data


More reference expression data

Gene ontology
Molecular function	transmembrane signaling receptor activity signaling receptor binding ubiquitin protein ligase binding protein binding signal transducer activity PDZ domain binding G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity
Cellular component	integral component of membrane membrane plasma membrane Golgi apparatus Wnt-Frizzled-LRP5/6 complex
Biological process	positive regulation of protein phosphorylation positive regulation of JUN kinase activity cell surface receptor signaling pathway G protein-coupled receptor signaling pathway angiogenesis positive regulation of transcription by RNA polymerase II multicellular organism development negative regulation of transcription by RNA polymerase II neuron differentiation signal transduction Wnt signaling pathway T cell differentiation in thymus non-canonical Wnt signaling pathway canonical Wnt signaling pathway
Sources:Amigo / QuickGO

Species

Human

Mouse


8325


14370


ENSG00000177283


ENSMUSG00000036904


Q9H461


Q61091

RefSeq (mRNA)


NM_031866


NM_008058

RefSeq (protein)


NP_114072


NP_032084

Location (UCSC)

Chr 10: 35.64 – 35.64 Mb

Chr 18: 9.21 – 9.22 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177283 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036904 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.

^ ^a ^b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. doi:10.1074/jbc.271.8.4468. PMID 8626800.

Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.

Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007. S2CID 4400159.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. Bibcode:2001CBio...11..951S. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. S2CID 15702819.

Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature. 412 (6842): 86–90. Bibcode:2001Natur.412...86D. doi:10.1038/35083601. PMID 11452312. S2CID 4303237.

Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. doi:10.1006/bbrc.2001.5430. PMID 11520064.

Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.

Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084. S2CID 18567677.

External links

"Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

t

e

Retrieved from "https://en.wikipedia.org/w/index.php?title=Frizzled-8&oldid=1216324573" Last edited on 30 March 2024, at 10:54

Languages

●Cymraeg ●فارسی ●Српски / srpski ●Srpskohrvatski / српскохрватски ●Татарча / tatarça ●Українська

●This page was last edited on 30 March 2024, at 10:54 (UTC). ●Content is available under CC BY-SA 4.0 unless otherwise noted. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Terms of Use ●Desktop