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Inositol monophosphatase 2





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Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[4][5] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

IMPA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIMPA2, inositol monophosphatase 2
External IDsOMIM: 605922; MGI: 2149728; HomoloGene: 22799; GeneCards: IMPA2; OMA:IMPA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3613

114663

Ensembl

ENSG00000141401

n/a

UniProt

O14732

Q91UZ5

RefSeq (mRNA)

NM_014214

NM_053261

RefSeq (protein)

NP_055029

NP_444491

Location (UCSC)Chr 18: 11.98 – 12.03 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141401 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233. S2CID 24336959.
  • ^ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".
  • ^ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.

    • Further reading

    edit
  • Yoshikawa T, Padigaru M, Karkera JD, Sharma M, Berrettini WH, Esterling LE, Detera-Wadleigh SD (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry. 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID 10822344. S2CID 25662931.
  • Sjøholt G, Gulbrandsen AK, Løvlie R, Berle JØ, Molven A, Steen VM (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry. 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID 10822345. S2CID 21428994.
  • Yoon IS, Li PP, Siu KP, Kennedy JL, Cooke RG, Parikh SV, Warsh JJ (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry. 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID 11673796. S2CID 26050322.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA. 9 (12): 1532–41. doi:10.1261/rna.5143303. PMC 1370506. PMID 14624008.
  • Sjøholt G, Ebstein RP, Lie RT, Berle JØ, Mallet J, Deleuze JF, Levinson DF, Laurent C, Mujahed M (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry. 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID 14699425. S2CID 28747842.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nakayama J, Yamamoto N, Hamano K, Iwasaki N, Ohta M, Nakahara S, Matsui A, Noguchi E, Arinami T (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology. 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID 15557493. S2CID 20201724.
  • Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.
  • Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology. 32 (8): 1727–37. doi:10.1038/sj.npp.1301307. PMID 17251911.
  • Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, Hanawa-Suetsugu K, Yoshikawa T, Shirouzu M (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins. 67 (3): 732–42. doi:10.1002/prot.21299. PMID 17340635. S2CID 46602105.
  • Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID 17388992. S2CID 36906656.
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    Last edited on 27 January 2024, at 03:30  





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