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SLC8B1

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Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 is a protein that in humans is encoded by the SLC8B1 gene.^[5]

SLC8B1

Identifiers

SLC8B1, NCKX6, NCLX, SLC24A6, solute carrier family 8 member B1

External IDs

OMIM: 609841; MGI: 2180781; HomoloGene: 41602; GeneCards: SLC8B1; OMA:SLC8B1 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.13	Start	113,298,759 bp^[1]
Band	12q24.13	End	113,359,493 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	120,649,233 bp^[2]
Band	5\|5 F	End	120,672,089 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

left adrenal cortex

right adrenal gland

right adrenal cortex

left ovary

right ovary

spleen

mucosa of transverse colon

sural nerve

granulocyte

epithelium of colon

Top expressed in

granulocyte

stroma of bone marrow

decidua

left lobe of liver

lip

tibiofemoral joint

yolk sac

left colon

gastrula

mesenteric lymph nodes

More reference expression data

n/a

Gene ontology
Molecular function	protein homodimerization activity identical protein binding antiporter activity calcium:cation antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
Cellular component	integral component of membrane membrane plasma membrane mitochondrial crista mitochondrion integral component of mitochondrial membrane sarcolemma mitochondrial inner membrane
Biological process	sodium ion transmembrane transport regulation of cytosolic calcium ion concentration glucose homeostasis response to stimulus regulation of insulin secretion sodium ion transport ion transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium ion transport transmembrane transport mitochondrial calcium ion transmembrane transport mitochondrial calcium ion homeostasis calcium export from the mitochondrion regulation of lymphocyte chemotaxis regulation of store-operated calcium entry
Sources:Amigo / QuickGO

Species

Human

Mouse


80024


170756


ENSG00000089060


ENSMUSG00000032754


Q6J4K2


Q925Q3

RefSeq (mRNA)


NM_024959 NM_001330466 NM_001358345


NM_001177594 NM_001177595 NM_133221

RefSeq (protein)


NP_001317395 NP_079235 NP_001345274


NP_001171065 NP_001171066 NP_573484

Location (UCSC)

Chr 12: 113.3 – 113.36 Mb

Chr 5: 120.65 – 120.67 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

SLC24A6 belongs to a family of Potassium-dependent sodium-calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089060 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032754 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".

^ Cai X, Lytton J (February 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Further reading

Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (June 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.

Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (June 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.

Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (October 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=SLC8B1&oldid=1116599467" Last edited on 17 October 2022, at 11:23

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