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Alpha-2A adrenergic receptor





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(Redirected from Α2A-adrenergic receptor)
  

The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.[5]

ADRA2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A
External IDsOMIM: 104210; MGI: 87934; HomoloGene: 47944; GeneCards: ADRA2A; OMA:ADRA2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

150

11551

Ensembl

ENSG00000150594

ENSMUSG00000033717

UniProt

P08913

Q01338

RefSeq (mRNA)

NM_000681

NM_007417

RefSeq (protein)

NP_000672

NP_031443

Location (UCSC)Chr 10: 111.08 – 111.08 MbChr 19: 54.03 – 54.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor

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α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity[6]

Gene

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This gene encodes α2A subtype and it contains no introns in either its codingoruntranslated sequences.[5]

Ligands

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Agonists

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Antagonists

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See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150594 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033717 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ a b "Entrez Gene: ADRA2A adrenergic, alpha-2A-, receptor".
  • ^ Hein, Lutz; Altman, John D.; Kobilka, Brian K. (1999). "Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission". Nature. 402 (6758): 181–184. Bibcode:1999Natur.402..181H. doi:10.1038/46040. PMID 10647009. S2CID 205047992.
  • ^ Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, et al. (September 2022). "Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor". Science. 377 (6614): eabn7065. doi:10.1126/science.abn7065. PMC 10360211. PMID 36173843.
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    Further reading

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  • Surprenant A, Horstman DA, Akbarali H, Limbird LE (Aug 1992). "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents". Science. 257 (5072): 977–80. Bibcode:1992Sci...257..977S. doi:10.1126/science.1354394. PMID 1354394.
  • Handy DE, Gavras H (Nov 1992). "Promoter region of the human alpha 2A adrenergic receptor gene". The Journal of Biological Chemistry. 267 (33): 24017–22. doi:10.1016/S0021-9258(18)35938-6. PMID 1385431.
  • Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK (Aug 1991). "A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists". The Journal of Biological Chemistry. 266 (23): 15488–92. doi:10.1016/S0021-9258(18)98642-4. PMID 1678390.
  • Wang CD, Buck MA, Fraser CM (Aug 1991). "Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists". Molecular Pharmacology. 40 (2): 168–79. PMID 1678850.
  • Chhajlani V, Rangel N, Uhlén S, Wikberg JE (Mar 1991). "Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR". FEBS Letters. 280 (2): 241–4. doi:10.1016/0014-5793(91)80301-I. PMID 1849485. S2CID 26642747.
  • Guyer CA, Horstman DA, Wilson AL, Clark JD, Cragoe EJ, Limbird LE (Oct 1990). "Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs". The Journal of Biological Chemistry. 265 (28): 17307–17. doi:10.1016/S0021-9258(17)44904-0. PMID 2170371.
  • Fraser CM, Arakawa S, McCombie WR, Venter JC (Jul 1989). "Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation". The Journal of Biological Chemistry. 264 (20): 11754–61. doi:10.1016/S0021-9258(18)80130-2. PMID 2568356.
  • Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW (Oct 1987). "Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor". Science. 238 (4827): 650–6. Bibcode:1987Sci...238..650K. doi:10.1126/science.2823383. PMID 2823383.
  • Lynch CJ, Steer ML (Apr 1981). "Evidence for high and low affinity alpha 2-receptors. Comparison of [3H]norepinephrine and [3H]phentolamine binding to human platelet membranes". The Journal of Biological Chemistry. 256 (7): 3298–303. doi:10.1016/S0021-9258(19)69606-7. PMID 6259160.
  • Eason MG, Moreira SP, Liggett SB (Mar 1995). "Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor". The Journal of Biological Chemistry. 270 (9): 4681–8. doi:10.1074/jbc.270.9.4681. PMID 7876239.
  • Grassie MA, Milligan G (Mar 1995). "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts". The Biochemical Journal. 306 (Pt 2): 525–30. doi:10.1042/bj3060525. PMC 1136549. PMID 7887906.
  • Shilo L, Sakaue M, Thomas JM, Philip M, Hoffman BB (Jan 1994). "Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene". Cellular Signalling. 6 (1): 73–82. doi:10.1016/0898-6568(94)90062-0. PMID 8011430.
  • Valet P, Senard JM, Devedjian JC, Planat V, Salomon R, Voisin T, Drean G, Couvineau A, Daviaud D, Denis C (May 1993). "Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa". The Journal of Clinical Investigation. 91 (5): 2049–57. doi:10.1172/JCI116427. PMC 288203. PMID 8098045.
  • Alblas J, van Corven EJ, Hordijk PL, Milligan G, Moolenaar WH (Oct 1993). "Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts". The Journal of Biological Chemistry. 268 (30): 22235–8. doi:10.1016/S0021-9258(18)41514-1. PMID 8226727.
  • Klein U, Ramirez MT, Kobilka BK, von Zastrow M (Aug 1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". The Journal of Biological Chemistry. 272 (31): 19099–102. doi:10.1074/jbc.272.31.19099. PMID 9235896.
  • Bétuing S, Daviaud D, Pagès C, Bonnard E, Valet P, Lafontan M, Saulnier-Blache JS (Jun 1998). "Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes". The Journal of Biological Chemistry. 273 (25): 15804–10. doi:10.1074/jbc.273.25.15804. PMID 9624180.
  • Prezeau L, Richman JG, Edwards SW, Limbird LE (May 1999). "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes". The Journal of Biological Chemistry. 274 (19): 13462–9. doi:10.1074/jbc.274.19.13462. PMID 10224112.
  • Hein L, Altman JD, Kobilka BK (Nov 1999). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission". Nature. 402 (6758): 181–4. Bibcode:1999Natur.402..181H. doi:10.1038/46040. PMID 10647009. S2CID 205047992.
  • Schaak S, Cussac D, Cayla C, Devedjian JC, Guyot R, Paris H, Denis C (Aug 2000). "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells". Gut. 47 (2): 242–50. doi:10.1136/gut.47.2.242. PMC 1728001. PMID 10896916.


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    Last edited on 17 May 2024, at 05:44  





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