South Carolina elected its members October 12–13, 1818.
| District | Incumbent | This race | |||
|---|---|---|---|---|---|
| Member | Party | First elected | Results | Candidates | |
| South Carolina 1 | Henry Middleton | Democratic-Republican | 1814 | Incumbent retired. New member elected. Democratic-Republican hold. |
√ Charles Pinckney (Democratic-Republican) 49.0% Daniel Elliott Huger (Democratic-Republican) 34.1% William Crafts Jr. (Federalist) 16.9% |
| South Carolina 2 | William Lowndes | Democratic-Republican | 1810 | Incumbent re-elected. | √ William Lowndes (Democratic-Republican) 100% |
| South Carolina 3 | James Ervin | Democratic-Republican | 1816 | Incumbent re-elected. | √ James Ervin (Democratic-Republican) 100% |
| South Carolina 4 | Joseph Bellinger | Democratic-Republican | 1816 | Incumbent retired. New member elected. Democratic-Republican hold. |
√ James Overstreet (Democratic-Republican) 41.0% John J. Chappell (Democratic-Republican) 35.2% John M. Felder (Federalist) 23.8% |
| South Carolina 5 | Starling Tucker | Democratic-Republican | 1816 | Incumbent re-elected. | √ Starling Tucker (Democratic-Republican) 50.8% William Brown (Democratic-Republican) 28.5% Philip E. Pearson (Democratic-Republican) 20.7% |
| South Carolina 6 | Eldred Simkins | Democratic-Republican | 1818 (Special) | Incumbent re-elected. | √ Eldred Simkins (Democratic-Republican) 54.1% Joseph Black (Democratic-Republican) 25.9% William Butler (Democratic-Republican) 19.9% |
| South Carolina 7 | Elias Earle | Democratic-Republican | 1804 1814 (Lost) 1816 |
Incumbent re-elected. | √ Elias Earle (Democratic-Republican) 53.7% John H. Harrison (Democratic-Republican) 46.3% |
| South Carolina 8 | Wilson Nesbitt | Democratic-Republican | 1816 | Incumbent retired. New member elected. Democratic-Republican hold. |
√ John McCreary (Democratic-Republican) 100% |
| South Carolina 9 | Stephen D. Miller | Democratic-Republican | 1816 | Incumbent retired. New member elected. Democratic-Republican hold. |
√ Joseph Brevard (Democratic-Republican) 91.9%[a] James C. Postell (Federalist) 8.1% |
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