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6-Hydroxymelatonin





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6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metaboliteofmelatonin.[1] Similar to melatonin, 6-OHM is a full agonist of the MT1 and MT2 receptors.[2][3] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin.[4][5]

6-Hydroxymelatonin
Names
Preferred IUPAC name

N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide

Other names

6-Oxymelatonin

Identifiers

CAS Number

3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.164.426 Edit this at Wikidata
KEGG

PubChem CID
UNII

CompTox Dashboard (EPA)

  • InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)

    Key: OMYMRCXOJJZYKE-UHFFFAOYSA-N

  • InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)

    Key: OMYMRCXOJJZYKE-UHFFFAOYAK

  • CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)O

Properties

Chemical formula

 C13H16N2O3
Molar mass 248.282 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

See also

edit

References

edit
  1. ^ Hardeland R (2010). "Melatonin metabolism in the central nervous system". Curr Neuropharmacol. 8 (3): 168–81. doi:10.2174/157015910792246164. PMC 3001211. PMID 21358968.
  • ^ Dubocovich ML (1988). "Pharmacology and function of melatonin receptors". FASEB J. 2 (12): 2765–73. doi:10.1096/fasebj.2.12.2842214. PMID 2842214. S2CID 45788574.
  • ^ Browning, Christopher; Beresford, Isabel; Fraser, Neil; Giles, Heather (2000). "Pharmacological characterization of human recombinant melatonin mt1and MT2receptors". British Journal of Pharmacology. 129 (5): 877–886. doi:10.1038/sj.bjp.0703130. ISSN 0007-1188. PMC 1571913. PMID 10696085.
  • ^ Maharaj DS, Glass BD, Daya S (2007). "Melatonin: new places in therapy". Biosci. Rep. 27 (6): 299–320. doi:10.1007/s10540-007-9052-1. PMID 17828452. S2CID 32437175.
  • ^ Álvarez-Diduk R, Galano A, Tan DX, Reiter RJ (2015). "N-Acetylserotonin and 6-Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin". J Phys Chem B. 119 (27): 8535–43. doi:10.1021/acs.jpcb.5b04920. PMID 26079042.


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    Last edited on 28 March 2024, at 02:59  





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