The Century 424 was a four-axle, 2,400 hp (1,790 kW) diesel-electric locomotive. 190 were built between April 1963 and May 1967. Cataloged as a part of Alco's Century line of locomotives, the C424 was intended to replace the earlier RS-27 model and offered as a lower-priced alternative to the C425. Montreal Locomotive Works also built this locomotive as MLW Century 424.
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| Owner | Quantity | Numbers | Notes |
|---|---|---|---|
| Belt Railway of Chicago | 6 | 600–605 | At least one (#603) now Western New York & Pennsylvania Railroad |
| Erie Lackawanna Railway | 15 | 2401–2415 | |
| Erie Mining Company | 1 | 500 | |
| Ferrocarriles Nacionales de México | 45 | 8100-8144 | |
| Green Bay and Western Railroad | 4 | 311–314 | |
| Pennsylvania Railroad | 1 | 2415 | rebuilt from RS27 demonstrator 640-1 |
| Reading Company | 10 | 5201–5210 | |
| Spokane, Portland and Seattle Railway | 7 | 300–306 | To Burlington Northern 4240–4246. |
| Toledo, Peoria and Western Railway | 2 | 800–801 | Later sold to the Morristown & Erie Railway as #18 and 19. #19 preserved by Tri-State Railway Historical Society. #18 preserved by the Illinois Railway Museum in Union, IL. |
| Wabash Railroad | 7 | B900-B906 | Originally supposed to be NDM 8100–8106, but the order was canceled and the units were sold to Wabash. They were prohibited from being used as lead units due to the controls being labelled in Spanish. |
| Total | 98 |
| Owner | Quantity | Numbers | Notes |
|---|---|---|---|
| Canadian National Railway | 41 | 3200–3240 | |
| Canadian Pacific Railway | 51 | 8300, 4201–4250 | 8300 renumbered 4200. 4241 to Cuyahoga Valley Scenic Railway |
| Total | 92 |
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