Home  

Random  

Nearby  



Log in  



Settings  



Donate  



About Wikipedia  

Disclaimers  



Wikipedia





Amtolmetin guacil





Article  

Talk  



Language  

Watch  

Edit  





Amtolmetin guacil is a non-steroidal anti-inflammatory drug (NSAID). It is a prodrugoftolmetin sodium.[1]

Amtolmetin guacil
Clinical data
Other namesST-679
ATC code
  • none
Identifiers
  • (2-methoxyphenyl) 2-[ [2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetyl]ami

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.207.038 Edit this at Wikidata
Chemical and physical data
FormulaC24H24N2O5
Molar mass420.465 g·mol−1
3D model (JSmol)
  • O=C(c1ccc(n1C)CC(=O)NCC(=O)Oc2ccccc2OC)c3ccc(cc3)C

  • InChI=1S/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27) checkY

  • Key:CWJNMKKMGIAGDK-UHFFFAOYSA-N checkY

 ☒NcheckY (what is this?)  (verify)

Background

edit

Tolmetin sodium is an approved NSAID, marketed for the treatment of rheumatoid arthritis, osteoarthritis and juvenile rheumatoid arthritis.[2] In humans, tolmetin sodium is absorbed rapidly with peak plasma levels observed 30 minutes after administration. It is eliminated rapidly with a mean plasma elimination t½ of approximately 1 hour. The preparation of slow release formulations or chemical modification of NSAIDs to form prodrugs has been suggested as a method to reduce the gastrotoxicity of these agents.

Amtolmetin guacil is a non-acidic prodrug of tolmetin, having NSAID properties similar to tolmetin with additional analgesic, antipyretic, and gastro protective properties. Amtolmetin is formed by amidation of tolmetin by glycine.

Pharmacology

edit

Mechanism of action

edit

Amtolmetin guacil stimulates capsaicin receptors present on gastrointestinal walls, because of presence of vanillic moiety and also releases NO which is gastro protective. It also inhibits prostaglandin synthesis and cyclooxygenase (COX).

References

edit
  1. ^ Tsvetkova E, Denisov L, Nasonov E (2017). "AB0798 Amtolmetin guacil-effective and good safe nonsteroidal anti-inflammatory drug in knee osteoarthritis patients with dyspepsia". Annals of the Rheumatic Diseases. 76 (Suppl 2): 1337.2–1337. doi:10.1136/annrheumdis-2017-eular.5253.
  • ^ Garg A, Shoeb A, Moodahadu LS, Sharma A, Gandhi A, Akku S (2016). "Amtolmetin: A Reappraisal of NSAID with Gastroprotection". Arthritis. 2016: 7103705. doi:10.1155/2016/7103705. PMC 4820613. PMID 27092274.

  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Amtolmetin_guacil&oldid=1182071910"
     



    Last edited on 26 October 2023, at 23:40  





    Languages

     


    Српски / srpski
    Srpskohrvatski / српскохрватски
    Українська
     

    Wikipedia


    This page was last edited on 26 October 2023, at 23:40 (UTC).

    Content is available under CC BY-SA 4.0 unless otherwise noted.



    Privacy policy

    About Wikipedia

    Disclaimers

    Contact Wikipedia

    Code of Conduct

    Developers

    Statistics

    Cookie statement

    Terms of Use

    Desktop