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Early life
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Ardem Patapoutian (Armenian : Արտեմ Փաթափութեան ) was born to a Lebanese Armenian family in Beirut , Lebanon.[2 ] [4 ] [5 ] His father, Sarkis Patapoutian (better known by the pen name Sarkis Vahakn [hy ] ), is a poet and an accountant,[6 ] while his mother, Haiguhi Adjemian, was the principal of an Armenian school in Beirut. He has a brother, Ara, and a sister, Houry.[7 ] His grandparents settled in Lebanon from Hadjin after surviving the Armenian Genocide .[8 ] [9 ] [10 ]
He is childhood friends with journalist and author Vicken Cheterian .[11 ] He attended the Demirdjian and Hovagimian Armenian schools in Beirut.[11 ] He enrolled at the American University of Beirut for a year before emigrating to the United States in 1986.[5 ] [12 ] He received a B.S. degree in cell and developmental biology from the University of California, Los Angeles in 1990 and a Ph.D. degree in biology from the California Institute of Technology in 1996 under direction of Barbara Wold .[13 ] [5 ] [14 ]
As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the University of California, San Francisco .[15 ] In 2000, he became an assistant professor at the Scripps Research Institute.[16 ] Between 2000 and 2014, he had an additional research position for the Novartis Research Foundation.[17 ] Since 2014, Patapoutian has been an investigator for the Howard Hughes Medical Institute (HHMI).[14 ]
Personal life
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Research
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Patapoutian's research is into the biological receptors for temperature and touch (nociception ).[3 ] The knowledge is used to develop treatments for a range of diseases, including chronic pain.[22 ] The discoveries made it possible to understand how heat, cold and mechanical forces trigger nerve impulses.[22 ]
Patapoutian researches the signal transduction of sensors. Patapoutian and co-workers inactivated genes.[23 ] In this way, they identified the gene, that made the cells insensitive for touch.[23 ] The channel for the sense of touch was called PIEZO1 (transl. pressure ).[23 ] Through its similarity to PIEZO1, a second gene was discovered and named PIEZO2 .[24 ] This ion channel , the more important of the two mechanoreceptors, is essential for the sense of touch.[24 ] [25 ] PIEZO1 and PIEZO2 channels have been shown to regulate additional important physiological processes including blood pressure, respiration and urinary bladder control.[24 ]
Patapoutian also made significant contributions to the identification of novel ion channels and receptors that are activated by temperature, mechanical forces or increased cell volume.[26 ] [27 ] Patapoutian and co-workers were able to show that these ion channels play an outstanding role in the sensation of temperature, in the sensation of touch, in proprioception ,[28 ] in the sensation of pain and in the regulation of vascular tone. More recent work uses functional genomics techniques to identify and characterize mechanosensitive ion channels (mechanotransduction ).[16 ] [29 ] [30 ] [31 ]
Awards and honors
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Patapoutian on a 2022 stamp of Armenia
Nobel Prize in Physiology or Medicine 2021: Discovery of TRPV1 and PIEZO2
Patapoutian has an h-index of 68 according to Google Scholar ,[32 ] and of 63 according to Scopus [33 ] (As of May 2020[update] ). He has been a Fellow of the American Association for the Advancement of Science since 2016, a member of the National Academy of Sciences since 2017[34 ] and of the American Academy of Arts and Sciences since 2020.[35 ]
In 2017, Patapoutian received the W. Alden Spencer Award ,[36 ] in 2019 the Rosenstiel Award ,[37 ] in 2020 the Kavli Prize for Neuroscience,[38 ] and the BBVA Foundation Frontiers of Knowledge Award in Biology / Biomedicine.[39 ]
In 2021, he was awarded the Nobel Prize in Physiology or Medicine jointly with David Julius for their discoveries of receptors for temperature and touch .[3 ] [40 ] [41 ]
In October 2021 President of Lebanon Michel Aoun awarded Patapoutian the Lebanese Order of Merit .[42 ]
In December 2021, Patapoutian received the American Academy of Achievement’s Golden Plate Award presented by Awards Council member Frances Arnold .[43 ]
In 2022, Patapoutian was named by Carnegie Corporation of New York as an honoree of the Great Immigrants Award .[44 ]
Recognition in Armenia
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Patapoutian, the first Armenian Nobel laureate, received a hero's welcome when he visited Armenia in June 2022. Prime Minister Nikol Pashinyan awarded him the Order of St. Mesrop Mashtots ,[45 ] while the Armenian National Academy of Sciences elected him an honorary member,[46 ] and the Yerevan State Medical University awarded him an honorary doctorate.[47 ] Patapoutian gifted a replica of his Nobel medal to the History Museum of Armenia .[48 ] [49 ] HayPost issued a stamp dedicated to him.[50 ]
Selected publications
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PIEZO1 + PIEZO2
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Coste, B.; Mathur, J.; Schmidt, M.; Earley, T. J.; Ranade, S.; Petrus, M. J.; Dubin, A. E.; Patapoutian, A. (September 2, 2010). "Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels" . Science . 330 (6000). American Association for the Advancement of Science (AAAS): 55–60. Bibcode :2010Sci...330...55C . doi :10.1126/science.1193270 . ISSN 0036-8075 . PMC 3062430 . PMID 20813920 . [23 ]
Coste, Bertrand; Xiao, Bailong; Santos, Jose S.; Syeda, Ruhma; Grandl, Jörg; Spencer, Kathryn S.; Kim, Sung Eun; Schmidt, Manuela; Mathur, Jayanti; Dubin, Adrienne E.; Montal, Mauricio; Patapoutian, Ardem (February 19, 2012). "Piezo proteins are pore-forming subunits of mechanically activated channels" . Nature . 483 (7388). Springer Science and Business Media LLC: 176–181. Bibcode :2012Natur.483..176C . doi :10.1038/nature10812 . ISSN 0028-0836 . PMC 3297710 . PMID 22343900 .
Kim, Sung Eun; Coste, Bertrand; Chadha, Abhishek; Cook, Boaz; Patapoutian, Ardem (February 19, 2012). "The role of Drosophila Piezo in mechanical nociception" . Nature . 483 (7388). Springer Science and Business Media LLC: 209–212. Bibcode :2012Natur.483..209K . doi :10.1038/nature10801 . ISSN 0028-0836 . PMC 3297676 . PMID 22343891 .
PIEZO2
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Ranade, Sanjeev S.; Woo, Seung-Hyun; Dubin, Adrienne E.; Moshourab, Rabih A.; Wetzel, Christiane; Petrus, Matt; Mathur, Jayanti; Bégay, Valérie; Coste, Bertrand; Mainquist, James; Wilson, A. J. (December 2014). "Piezo2 is the major transducer of mechanical forces for touch sensation in mice" . Nature . 516 (7529): 121–125. Bibcode :2014Natur.516..121R . doi :10.1038/nature13980 . ISSN 1476-4687 . PMC 4380172 . PMID 25471886 . [25 ]
Woo, Seung-Hyun; Ranade, Sanjeev; Weyer, Andy D.; Dubin, Adrienne E.; Baba, Yoshichika; Qiu, Zhaozhu; Petrus, Matt; Miyamoto, Takashi; Reddy, Kritika; Lumpkin, Ellen A.; Stucky, Cheryl L.; Patapoutian, Ardem (April 6, 2014). "Piezo2 is required for Merkel-cell mechanotransduction" . Nature . 509 (7502). Springer Science and Business Media LLC: 622–626. Bibcode :2014Natur.509..622W . doi :10.1038/nature13251 . ISSN 0028-0836 . PMC 4039622 . PMID 24717433 .
References
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^ a b c "The Nobel Prize in Physiology or Medicine 2021" . NobelPrize.org . Archived from the original on October 4, 2021. Retrieved October 4, 2021 .
^ "Americans Julius and Patapoutian win 2021 Nobel Prize in Medicine" . The Indian Express . October 4, 2021. Retrieved October 5, 2021 .
^ a b c d "Scripps Research neurobiologist Ardem Patapoutian elected to American Academy of Arts and Sciences" . Scripps Research . April 30, 2020. Archived from the original on March 10, 2021. Retrieved October 5, 2021 .
^ Braidy, Nour (October 12, 2021). "Ardem Patapoutian: The journey of a boy from Beirut who won the Nobel Prize" . L'Orient-Le Jour . Archived from the original on November 6, 2021.
^ "Նոբելյան մրցանակ է շնորհվել հայազգի գիտնական Արտեմ Փաթափությանին" . sci.am (in Armenian). National Academy of Sciences of Armenia . October 6, 2021. Archived from the original on October 28, 2021.
^ Patapoutian, Ardem (April 24, 2022). "The Armenian Genocide is still denied and ignored by many but is commemorated by Armenians around the globe on April 24 (107th anniversary this year). Today I am thinking of my ancestors who perished and those who survived and started a new life in Lebanon" . Twitter. Archived from the original on May 7, 2022.
^ " 'My family's history is represented here' – Ardem Patapoutian visits Armenian Genocide Memorial" . Armenpress . June 16, 2022. Archived from the original on June 25, 2022.
^ "ARDEM PATAPOUTIAN WINS NOBEL PRIZE IN MEDICINE" . Armenianprelacy.org .
^ a b Taryan, Mari (October 5, 2021). "Արտեմ Փաթափությանի մանկությունը՝ բասկետբոլի եւ պատերազմի արանքում" . mediamax.am (in Armenian). Archived from the original on November 8, 2021.
^ "Nobel Prize for AUB alumnus and former student Ardem Patapoutian" . American University of Beirut . October 5, 2021. Retrieved October 5, 2021 .
^ Patapoutian, Ardem (1996). The Role of the MyoD Family Genes During Mouse Development (Ph.D. thesis). California Institute of Technology. OCLC 35966904 . ProQuest 304282071 .
^ a b "Ardem Patapoutian" . www.kavliprize.org . March 12, 2021. Archived from the original on June 24, 2021. Retrieved June 23, 2021 .
^ "Scripps Research neuroscientist Ardem Patapoutian receives 2021 Nobel Prize in Physiology" . Scripps Research . October 4, 2021. Retrieved October 5, 2021 .
^ a b "Ardem Patapoutian" . Scripps Research . Archived from the original on February 2, 2021. Retrieved October 4, 2021 .
^ "Medizin-Nobelpreis für Entschlüsselung des Taststinns" . tagesschau.de (in German). October 4, 2021. Retrieved October 6, 2021 .
^ Robbins, Gary (December 9, 2021). "Del Mar's Ardem Patapoutian receives Nobel Prize during special ceremony in Irvine" . Del Mar Times . The San Diego Union-Tribune . Archived from the original on December 9, 2021.
^ Robbins, Gary (November 7, 2021). "San Diego's Ardem Patapoutian experiences the dizzying, fragile joy of winning the Nobel Prize" . The San Diego Union-Tribune . Archived from the original on December 25, 2021. ...Patapoutian and his wife, venture capitalist Nancy Hong...
^ "Nobel Prize Laureate Finds Out He Won While in Bed, Check Out Viral Picture Here" . The Quint . October 5, 2021. Archived from the original on October 5, 2021.
^ "New medicine laureate Ardem Patapoutian and his son Luca, watching the #NobelPrize press conference shortly after finding out the happy news" . Twitter . The Nobel Prize . October 4, 2021. Archived from the original on December 25, 2021.
^ a b "Medizin-Nobelpreis – US-Forscher David Julius und Ardem Patapoutian ausgezeichnet" . Deutschlandfunk (in German). April 15, 2019. Archived from the original on October 4, 2021. Retrieved October 4, 2021 .
^ a b c d "Nobel Prize in Medicine Awarded to David Julius and Ardem Patapoutian" . The New York Times . October 4, 2021. Retrieved October 4, 2021 .
^ a b c "The Nobel Prize in Physiology or Medicine 2021" . NobelPrize.org . October 4, 2021. Retrieved October 4, 2021 .
^ a b "Medizin-Nobelpreis: Wie Nervenzellen Temperaturen und Berührungen erkennen" . Deutsches Ärzteblatt (in German). October 4, 2021. Retrieved October 5, 2021 .
^ Syeda, Ruhma; Qiu, Zhaozhu; Dubin, Adrienne E.; Murthy, Swetha E.; Florendo, Maria N.; Mason, Daniel E.; Mathur, Jayanti; Cahalan, Stuart M.; Peters, Eric C.; Montal, Mauricio; Patapoutian, Ardem (January 28, 2016). "LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength" . Cell . 164 (3 ): 499–511. doi :10.1016/j.cell.2015.12.031 . ISSN 1097-4172 . PMC 4733249 . PMID 26824658 .
^ Qiu, Zhaozhu; Dubin, Adrienne E.; Mathur, Jayanti; Tu, Buu; Reddy, Kritika; Miraglia, Loren J.; Reinhardt, Jürgen; Orth, Anthony P.; Patapoutian, Ardem (2014). "SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel" . Cell . 157 (2 ). Elsevier BV: 447–458. doi :10.1016/j.cell.2014.03.024 . ISSN 0092-8674 . PMC 4023864 . PMID 24725410 .
^ Woo, Seung-Hyun; Lukacs, Viktor; de Nooij, Joriene C; Zaytseva, Dasha; Criddle, Connor R; Francisco, Allain; Jessell, Thomas M; Wilkinson, Katherine A; Patapoutian, Ardem (November 9, 2015). "Piezo2 is the principal mechanotransduction channel for proprioception" . Nature Neuroscience . 18 (12 ). Springer Science and Business Media LLC: 1756–1762. doi :10.1038/nn.4162 . ISSN 1097-6256 . PMC 4661126 . PMID 26551544 .
^ "Piezo channels in mechanotransduction: Sensory biology to disease – Ardem Patapoutian" . Wu Tsai Neurosciences Institute . December 17, 2019. Archived from the original on October 4, 2021. Retrieved October 4, 2021 .
^ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C; Engels, Ingo H; Petrassi, H Michael; Schumacher, Andrew M; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (May 22, 2015). "Chemical activation of the mechanotransduction channel Piezo1" . eLife . 4 . eLife Sciences Publications, Ltd. doi :10.7554/elife.07369 . ISSN 2050-084X . PMC 4456433 . PMID 26001275 .
^ Murthy, Swetha E.; Dubin, Adrienne E.; Patapoutian, Ardem (October 4, 2017). "Piezos thrive under pressure: mechanically activated ion channels in health and disease". Nature Reviews Molecular Cell Biology . 18 (12 ). Springer Science and Business Media LLC: 771–783. doi :10.1038/nrm.2017.92 . ISSN 1471-0072 . PMID 28974772 . S2CID 20977908 .
^ Ardem Patapoutian publications indexed by Google Scholar
^ Ardem Patapoutian publications indexed by the Scopus bibliographic database. (subscription required)
^ "Ardem Patapoutian" . www.nasonline.org . Archived from the original on June 3, 2020. Retrieved January 30, 2021 .
^ "Members Elected in 2020" . American Academy of Arts & Sciences . December 9, 2020. Archived from the original on January 22, 2021. Retrieved January 30, 2021 .
^ "The Thirty-Ninth Annual W. Alden Spencer Award and Lecture" . Kavli Institute for Brain Science . June 4, 2020. Archived from the original on December 27, 2020. Retrieved January 30, 2021 .
^ "Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research" . www.brandeis.edu . Archived from the original on June 15, 2021. Retrieved January 30, 2021 .
^ "2020 Kavli Prize in Neuroscience" . www.kavliprize.org . March 12, 2021. Archived from the original on June 24, 2021. Retrieved June 23, 2021 .
^ "Fundación BBVA" . FBBVA . Archived from the original on January 30, 2021. Retrieved January 30, 2021 .
^ "Armenian President congratulates Ardem Patapoutian on winning the Nobel Prize in Medicine" . Public Radio of Armenia . October 4, 2021. Retrieved October 5, 2021 .
^ "Armenian President congratulates Ardem Patapoutian on winning the Nobel Prize in Medicine" . Public Radio of Armenia . Retrieved October 15, 2021 .
^ "Nobel prize winner Ardem Patapoutian awarded Lebanese Order of Merit" . The National . October 6, 2021. Archived from the original on October 8, 2021.
^ "Golden Plate Awardees of the American Academy of Achievement" . www.achievement.org . American Academy of Achievement .
^ "Ardem Patapoutian" . Carnegie Corporation of New York . Retrieved June 10, 2024 .
^ "PM Pashinyan hosts Nobel Laureate Ardem Patapoutian, awards him with the Order of St. Mesrop Mashtots" . The Office to the Prime Minister of the Republic of Armenia. June 16, 2022. Archived from the original on June 22, 2022.
^ "Նոբելյան մրցանակի դափնեկիր Արտեմ Փաթափությանն ընտրվել է ՀՀ ԳԱԱ պատվավոր անդամ [Nobel Laureate Artem Pataputyan was elected an honorary member of the National Academy of Sciences of the Republic of Armenia]" . sci.am (in Armenian). National Academy of Sciences of Armenia. June 14, 2022. Archived from the original on June 20, 2022.
^ "First Armenian Nobel Prize winner Ardem Patapoutian is YSMU Honorary Doctor" . Yerevan State Medical University. June 14, 2022. Archived from the original on June 22, 2022.
^ Patapoutian, Ardem (June 15, 2022). "The 2nd (out of 3) replica medals has found a home at the History Museum of Armenia in Yerevan!" . Twitter . Archived from the original on July 2, 2022.
^ Ghazanchyan, Siranush (June 16, 2022). "Replica of Ardem Patapoutian's Nobel medal to be on display at History Museum of Armenia" . Public Radio of Armenia . Archived from the original on June 21, 2022.
^ "World famous Armenians. Ardem Patapoutian" . stamps.am . HayPost . June 14, 2022. Archived from the original on July 1, 2022.
External links
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Ardem_Patapoutian&oldid=1233895813 "
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