BNR/Asp-box repeat is a repetitive sequence of amino acids contained in some proteins. Many of these proteins contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes.
| BNR/Asp-box repeat | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of a bacterial sialidase.[1]
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| Identifiers | |||||||||
| Symbol | BNR | ||||||||
| Pfam | PF02012 | ||||||||
| Pfam clan | CL0434 | ||||||||
| InterPro | IPR002860 | ||||||||
| SCOP2 | 1euu / SCOPe / SUPFAM | ||||||||
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The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. The Asp-box itself adopts a well-defined beta-hairpin fold.[2][3] These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.[4]
Human genes encoding proteins containing this domain include: