Bepridil (trade name Vascor) is an diamine calcium channel blocker once used to treat angina pectoris. It is no longer sold in the United States.
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Trade names | Vascor |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699051 |
Routes of administration | Oral |
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Bioavailability | Well absorbed |
Protein binding | 99% |
Metabolism | Hepatic, CYP3A4-mediated |
Elimination half-life | 42 hours |
Excretion | Renal |
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Chemical and physical data | |
Formula | C24H34N2O |
Molar mass | 366.549 g·mol−1 |
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It is nonselective.[1]
It has been discussed as a possible option in the treatment of atrial fibrillation.[2]
It has been implicated in causing ventricular arrhythmia (torsades de pointes).
In June 2015 a research paper [3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.[4]
A research paper [5] showed that Bepridil inhibited cytopathogenic effects induced by SARS-CoV-2 in Vero E6 cells and in A549 cells in an in vitro assay.
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