Center for Pharmaceutical Research and Innovation

The Center for Pharmaceutical Research and Innovation (CPRI) is a University of Kentucky-based research center established by the University of Kentucky College of Pharmacy in 2012 to facilitate academic translational research and drug discovery/drug development. The UK CPRI specializes in natural product-based drug discovery from microbes found within unique environments including underground and surface coal mines, acid mine drainage and mine reclamation sites, thermal vents associated with underground coal mine fires (see coal seam fire)^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8] and deep-well drilling for carbon sequestration. CPRI also provides core support for medicinal chemistry, assay development and screening, rational drug design, computational chemistry, and ADMET. The Center collaborates with investigators focused on drug discovery or development research in the areas of cancer, drug and alcohol addiction, cardiovascular disease, infectious disease, regenerative medicine and neurodegenerative disease.

References

^ Ohlson, K. "Earth On Fire." Discover Magazine 2010, July–August Special Issue.

^ Wang, X; Shaaban, KA; Elshahawi, SI; Ponomareva, LV; Sunkara, M; Zhang, Y; Copley, GC; Hower, JC; Morris, AJ; Kharel, MK; Thorson, JS (23 August 2013). "Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15". Journal of Natural Products. 76 (8): 1441–7. doi:10.1021/np400231r. PMC 3862173. PMID 23944931.

^ Shaaban, KA; Wang, X; Elshahawi, SI; Ponomareva, LV; Sunkara, M; Copley, GC; Hower, JC; Morris, AJ; Kharel, MK; Thorson, JS (27 September 2013). "Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15". Journal of Natural Products. 76 (9): 1619–26. doi:10.1021/np400308w. PMC 3852429. PMID 23947794.

^ Wang, X; Elshahawi, SI; Shaaban, KA; Fang, L; Ponomareva, LV; Zhang, Y; Copley, GC; Hower, JC; Zhan, CG; Kharel, MK; Thorson, JS (Jan 17, 2014). "Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15". Organic Letters. 16 (2): 456–9. doi:10.1021/ol4033418. PMC 3964319. PMID 24341358.

^ Wang, X; Shaaban, KA; Elshahawi, SI; Ponomareva, LV; Sunkara, M; Copley, GC; Hower, JC; Morris, AJ; Kharel, MK; Thorson, JS (Aug 2014). "Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46". The Journal of Antibiotics. 67 (8): 571–5. doi:10.1038/ja.2014.37. PMC 4146655. PMID 24713874.

^ Shaaban, KA; Singh, S; Elshahawi, SI; Wang, X; Ponomareva, LV; Sunkara, M; Copley, GC; Hower, JC; Morris, AJ; Kharel, MK; Thorson, JS (March 2014). "Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2". The Journal of Antibiotics. 67 (3): 223–30. doi:10.1038/ja.2013.113. PMC 3969387. PMID 24252813.

^ Wang, X; Reynolds, AR; Elshahawi, SI; Shaaban, KA; Ponomareva, LV; Saunders, MA; Elgumati, IS; Zhang, Y; Copley, GC; Hower, JC; Sunkara, M; Morris, AJ; Kharel, MK; Van Lanen, SG; Prendergast, MA; Thorson, JS (5 June 2015). "Terfestatins B and C, new p-terphenyl glycosides produced by Streptomyces sp. RM-5-8". Organic Letters. 17 (11): 2796–9. doi:10.1021/acs.orglett.5b01203. PMC 4472964. PMID 25961722.

^ Shaaban, KA; Saunders, MA; Zhang, Y; Tran, T; Elshahawi, SI; Ponomareva, LV; Wang, X; Zhang, J; Copley, GC; Sunkara, M; Kharel, MK; Morris, AJ; Hower, JC; Tremblay, MS; Prendergast, MA; Thorson, JS (28 December 2016). "Spoxazomicin D and oxachelin C, potent neuroprotective carboxamides from the Appalachian coal fire-associated isolate Streptomyces sp. RM-14-6". Journal of Natural Products. 80 (1): 2–11. doi:10.1021/acs.jnatprod.6b00948. PMC 5337259. PMID 28029795.

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