Clofibrate (trade name Atromid-S) is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It belongs to the class of fibrates. It increases lipoprotein lipase activity to promote the conversion of VLDLtoLDL, and hence reduce the level of VLDL. It can increase the level of HDL as well.
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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Routes of administration | By mouth |
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Protein binding | Variable, 92–97% at therapeutic concentrations |
Metabolism | Hydrolyzedtoclofibric acid; hepatic glucuronidation |
Elimination half-life | Highly variable; average 18–22 hours. Prolonged in renal failure |
Excretion | Renal, 95 to 99% |
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ECHA InfoCard | 100.010.253 ![]() |
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Formula | C12H15ClO3 |
Molar mass | 242.70 g·mol−1 |
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Boiling point | 148 °C (298 °F) |
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It was patented in 1958 by Imperial Chemical Industries and approved for medical use in 1963.[1] Clofibrate was discontinued in 2002 due to adverse effects.
It can induce SIADH, syndrome of inappropriate secretion of antidiuretic hormone ADH (vasopressin). Clofibrate can also result in formation of cholesterol stones in the gallbladder.
The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering (47% more deaths during treatment with clofibrate and 5% after treatment with clofibrate) than the non-treated high cholesterol group. These deaths were due to a wide variety of causes other than heart disease, and remain "unexplained".[2]
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