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Cytidine triphosphate





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Cytidine triphosphate (CTP) is a pyrimidine nucleoside triphosphate. CTP, much like ATP, consists of a ribose sugar, and three phosphate groups. The major difference between the two molecules is the base used, which in CTP is cytosine.

Cytidine triphosphate
Skeletal formula of cytidine triphosphate as an anion (3- charge)
Space-filling model of the cytidine triphosphate molecule as an anion (4- charge)
Names
IUPAC name

Cytidine 5′-(tetrahydrogen triphosphate)

Systematic IUPAC name

O1-{[(2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate

Other names

CTP; Cytidine-5'-triphosphate

Identifiers

CAS Number

3D model (JSmol)
  • Interactive image
    • ChemSpider
    ECHA InfoCard 100.000.556 Edit this at Wikidata

    IUPHAR/BPS
    MeSH Cytidine+triphosphate

    PubChem CID
    UNII

    CompTox Dashboard (EPA)

    • InChI=1S/C9H13N3O5.3H3O4P/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;3*1-5(2,3)4/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);3*(H3,1,2,3,4)/t4-,6-,7-,8-;;;/m1.../s1 checkY

      Key: NPIWPFUCEAMYFN-LLWADOMFSA-N checkY

    • InChI=1/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

      Key: PCDQPRRSZKQHHS-XVFCMESIBL

    • InChI=1/C9H13N3O5.3H3O4P/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;3*1-5(2,3)4/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);3*(H3,1,2,3,4)/t4-,6-,7-,8-;;;/m1.../s1

      Key: NPIWPFUCEAMYFN-LLWADOMFBY

    • c1cn(c(=O)nc1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O

    • OP(O)(=O)O.OP(O)(=O)O.OP(O)(=O)O.N/C1=N/C(=O)N(/C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

    Properties

    Chemical formula

    		 C9H16N3O14P3
    Molar mass 483.156

    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    checkY verify (what is checkY☒N ?)

    Infobox references

    CTP is a substrate in the synthesis of RNA.

    CTP is a high-energy molecule similar to ATP, but its role as an energy coupler is limited to a much smaller subset of metabolic reactions. CTP is a coenzyme in metabolic reactions like the synthesis of glycerophospholipids, where it is used for activation and transfer of diacylglycerol and lipid head groups,[1] and glycosylation of proteins.

    CTP acts as an inhibitor of the enzyme aspartate carbamoyltransferase, which is used in pyrimidine biosynthesis.[2]

    See also

    edit

    References

    edit
    1. ^ Buchanan BB, Gruissem W, Jones RL (2000). Biochemistry & molecular biology of plants (1st ed.). American society of plant physiology. ISBN 978-0-943088-39-6.
  • ^ Blackburn, G. Michael. Nucleic Acids in Chemistry and Biology. The Royal Society of Chemistry, 2006, p. 119-120.

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Cytidine_triphosphate&oldid=1152505747"
      



    Last edited on 30 April 2023, at 17:02  





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    ●This page was last edited on 30 April 2023, at 17:02 (UTC).
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