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LGTN

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Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.^[5]^[6] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

EIF2D

Identifiers

EIF2D, HCA56, LGTN, eukaryotic translation initiation factor 2D

External IDs

OMIM: 613709; MGI: 109342; HomoloGene: 38244; GeneCards: EIF2D; OMA:EIF2D - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	206,571,292 bp^[1]
Band	1q32.1	End	206,612,465 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 E4\|1 56.9 cM	Start	131,080,918 bp^[2]
Band	1 E4\|1 56.9 cM	End	131,115,395 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

left ovary

body of uterus

right ovary

right uterine tube

glutes

muscle of thigh

parotid gland

body of pancreas

muscle layer of sigmoid colon

canal of the cervix

Top expressed in

Paneth cell

fossa

condyle

hair follicle

internal carotid artery

lacrimal gland

primitive streak

external carotid artery

endothelial cell of lymphatic vessel

epiblast

More reference expression data


More reference expression data

Gene ontology
Molecular function	translation initiation factor activity RNA binding signaling receptor activity
Cellular component	cytoplasm cytosolic small ribosomal subunit cytosol nuclear body
Biological process	translational initiation intracellular protein transport ribosome disassembly protein biosynthesis formation of translation preinitiation complex IRES-dependent viral translational initiation signal transduction
Sources:Amigo / QuickGO

Species

Human

Mouse


1939


16865


ENSG00000143486


ENSMUSG00000026427


P41214 Q5SY38


Q61211

RefSeq (mRNA)


NM_001201478 NM_006893


NM_001136070 NM_010709

RefSeq (protein)


NP_001188407 NP_008824


NP_001129542 NP_034839

Location (UCSC)

Chr 1: 206.57 – 206.61 Mb

Chr 1: 131.08 – 131.12 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.^[6]

See also

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143486 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026427 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( Pt 2) (2): 227–32. doi:10.1242/jcs.93.2.227. PMID 2482295.

^ ^a ^b "Entrez Gene: LGTN ligatin".

Further reading

Jakoi ER, Ross PE, Ping Ting-Beall H, Kaufman B, Vanaman TC (January 1987). "Ligatin: a peripheral membrane protein with covalently bound palmitic acid". The Journal of Biological Chemistry. 262 (3): 1300–4. doi:10.1016/S0021-9258(19)75786-X. PMID 3805022.

Gaston SM, Marchase RB, Jakoi ER (1982). "Brain ligatin: a membrane lectin that binds acetylcholinesterase". Journal of Cellular Biochemistry. 18 (4): 447–59. doi:10.1002/jcb.1982.240180406. PMID 7085778. S2CID 22975039.

Marchase RB, Koro LA, Kelly CM, McClay DR (1982). "A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion". Journal of Cellular Biochemistry. 18 (4): 461–8. doi:10.1002/jcb.1982.240180407. PMID 7085779. S2CID 44992995.

Jakoi ER, Kempe K, Gaston SM (1982). "Ligatin binds phosphohexose residues on acidic hydrolases". Journal of Supramolecular Structure and Cellular Biochemistry. 16 (2): 139–53. doi:10.1002/jsscb.1981.380160205. PMID 7299841.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (July 2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". Journal of Immunology. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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