Fasiplon

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Fasiplon (RU 33203) is a nonbenzodiazepine anxiolytic drug from the imidazopyrimidine family of drugs.

Fasiplon
Clinical data

ATC code	none
Identifiers
IUPAC name 6-Ethyl-7-methoxy-5-methyl-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-imidazo[1,2-a]pyrimidine
CAS Number	106100-65-6^Y
PubChem CID	208954
ChemSpider	181047^N
UNII	XCA050IPGB
ChEMBL	ChEMBL62735^N
CompTox Dashboard (EPA)	DTXSID70147512
Chemical and physical data
Formula	C₁₃H₁₅N₅O₂
Molar mass	273.296 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=NC(C2=CN3C(N=C(OC)C(CC)=C3C)=N2)=NO1
InChI InChI=1S/C13H15N5O2/c1-5-9-7(2)18-6-10(11-14-8(3)20-17-11)15-13(18)16-12(9)19-4/h6H,5H2,1-4H3^N Key:MEBYKPLMXIRYRQ-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Fasiplon binds strongly to benzodiazepine sites on the GABA_A receptor and has similar anxiolytic effects in animals, but with less sedativeormuscle relaxant action.^[1] It was developed by a team at Roussel Uclaf in the 1990s^[2]

References

^ Tully WR, Gardner CR, Gillespie RJ, Westwood R (July 1991). "2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors". Journal of Medicinal Chemistry. 34 (7): 2060–7. doi:10.1021/jm00111a021. PMID 1648620.

^ US Patent 5869481 Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making

Retrieved from "https://en.wikipedia.org/w/index.php?title=Fasiplon&oldid=1135227643" Last edited on 23 January 2023, at 11:48

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