Gallopamil (INN) is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of abnormal heart rhythms.[1]
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Other names | Methoxyverapamil |
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Formula | C28H40N2O5 |
Molar mass | 484.637 g·mol−1 |
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Chirality | Racemic mixture |
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The alkylation reaction of 3,4,5-trimethoxyphenylacetonitrile (1) and isopropyl chloride (2), using sodium amide as base gives the intermediate nitrile (3). A second alkylation with a specific alkyl chloride (4) yields gallopamil.[2][3][4]
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