Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis.
| glycerol kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
glycerol kinase dimer, E.Coli
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| Identifiers | |||||||||
| EC no. | 2.7.1.30 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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| glycerol kinase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GK | ||||||
| NCBI gene | 2710 | ||||||
| HGNC | 4289 | ||||||
| OMIM | 300474 | ||||||
| RefSeq | NM_000167 | ||||||
| UniProt | P32189 | ||||||
| Other data | |||||||
| EC number | 2.7.1.30 | ||||||
| Locus | Chr. X p21.3 | ||||||
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Glycerol kinase catalyzes the transfer of a phosphate from ATPtoglycerol thus forming glycerol 3-phosphate:
Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is:
This protein may use the morpheein model of allosteric regulation.[1]
Glycerol Kinase (alternative name, ATP:glycerol 3-phosphotransferase or Glycerokinase) adopts a ribonuclease H-like fold consisting of an alpha-beta 2-layer sandwich of CATH family 3.30.420.40. As of March 2010[update], there were 20 structures of this protein in the PDB, most of which are homodimeric.
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