Karyorrhexis (from Greek κάρυον karyon 'kernel, seed, nucleus' and ῥῆξις rhexis 'bursting') is the destructive fragmentation of the nucleus of a dying cell[1] whereby its chromatin is distributed irregularly throughout the cytoplasm.[2] It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis.
Inapoptosis, the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases.
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