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Lucrezia Gonzaga di Gazzuolo (1522 – 11 February 1576) was an Italian noblewoman known for her literary talents, and her association with Matteo Bandello. Bandello taught her mathematics, astronomy, rhetoric and logic, and wrote poetry in her honour, during his stay in Castel Goffredo at the court of Luigi Gonzaga. A volume of her letters was published in Venice in 1552, but some people believe Ortensio Lando was the author and not just the editor.
She was born in BozzolotoPirro Gonzaga, lord of Gazzuolo, member of a secondary branch of the Gonzaga family, and Camilla Bentivoglio. At the age of 14 she married Paolo Manfrone, and is sometimes known as Lucrezia Gonzaga Manfrona. She died in 1576 in Mantua.