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Nitecapone





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Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).[1][2] It was patented as an antiparkinson medication but was never marketed.[1]

Nitecapone
Skeletal formula
Space-filling model
Clinical data
ATC code
  • None
Identifiers

  • 3-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]pentane-2,4-dione

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H11NO6
Molar mass265.221 g·mol−1
3D model (JSmol)

  • [O-][N+](=O)c1cc(\C=C(/C(=O)C)C(=O)C)cc(O)c1O

  • InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3

  • Key:UPMRZALMHVUCIN-UHFFFAOYSA-N

See also

edit

References

edit
  1. ^ a b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978-0-412-46630-4. Retrieved 20 May 2012.
  • ^ Nissinen E, Lindén IB, Schultz E, Kaakkola S, Männistö PT, Pohto P (August 1988). "Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of Pharmacology. 153 (2–3): 263–9. doi:10.1016/0014-2999(88)90614-0. PMID 3181288.
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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Nitecapone&oldid=1201021753"
      



    Last edited on 30 January 2024, at 19:24  





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