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Phenindione





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Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU:D
  • Passes into breast milk
    • Routes of
    administration    		Oral
    ATC code
    Pharmacokinetic data
    Protein binding88%
    Elimination half-life5 to 10 hours
    Identifiers

    • 2-phenyl-1H-indene-1,3(2H)-dione

    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.001.323 Edit this at Wikidata
    Chemical and physical data
    FormulaC15H10O2
    Molar mass222.243 g·mol−1
    3D model (JSmol)

    • O=C2c1ccccc1C(=O)C2c3ccccc3

    • InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H checkY

    • Key:NFBAXHOPROOJAW-UHFFFAOYSA-N checkY

      (verify)

    Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1][2]

    References

    edit
    1. ^ Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920. S2CID 17052792.
  • ^ Sweetman SC, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. "Phenindione", p. 1369.
    • edit
     

    This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.

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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Phenindione&oldid=1157643567"
      



    Last edited on 30 May 2023, at 01:14  





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    ●This page was last edited on 30 May 2023, at 01:14 (UTC).
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