Ingenetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valinetomethionineatcodon 158.
SNP: rs4680 | |
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Name(s) | Val158Met, Val108/158Met, G1947A |
Gene | COMT |
Chromosome | 22 |
Region | Exon 3 |
External databases | |
Ensembl | Human SNPView |
dbSNP | 4680 |
HapMap | 4680 |
SNPedia | 4680 |
AlzGene | Meta-analysis Overview |
SzGene | Meta-analysis Overview |
The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour.
The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the SzGene database shows no or very little effect.[1]
Several personality genetics studies have examined the association of the polymorphism with personality traits including extroversion, risk aversion, and novelty seeking.[2][3][4][5][6]
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