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Sodium salicylate





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Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate (wintergreen oil) with an excess of sodium hydroxide.[4]

Sodium salicylate
Names
Preferred IUPAC name

Sodium 2-hydroxybenzoate

Other names

Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin

Identifiers

CAS Number

3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.000.181 Edit this at Wikidata
EC Number
  • 200-198-0
KEGG

PubChem CID
RTECS number
  • VO5075000
UNII

CompTox Dashboard (EPA)

  • InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 checkY

    Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M checkY

  • InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m

  • InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

    Key: ABBQHOQBGMUPJH-REWHXWOFAO

  • [Na+].O=C([O-])c1ccccc1O

Properties

Chemical formula

 C7H5NaO3
Molar mass 160.104 g/mol
Appearance White crystals
Melting point 200 °C (392 °F; 473 K)

Solubility in water

 25.08 g/100 g (-1.5 °C)
107.9 g/100 g (15 °C)
124.6 g/100 g (25 °C)
141.8 g/100 g (78.5 °C)
179 g/100 g (114 °C)[1]
Solubility Soluble in glycerol, 1,4-Dioxane, alcohol[1]
Solubilityinmethanol 26.28 g/100 g (15 °C)
34.73 g/100 g (67.2 °C)[1]
Pharmacology

ATC code

 N02BA04 (WHO)
Hazards
Occupational safety and health (OHS/OSH):

Main hazards

 Harmful

Eye hazards

 Irritant
GHS labelling:[3]

Pictograms

 GHS07: Exclamation mark

Signal word

 Warning

Hazard statements

 H314, H331, H400

Precautionary statements

 P210, P261, P273, P280, P305+P351+P338, P310
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
1
0

Autoignition
temperature

 250 °C (482 °F; 523 K)
Lethal dose or concentration (LD, LC):

LD50 (median dose)

 930 mg/kg (rats, oral)[2]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

☒N verify (what is checkY☒N ?)

Infobox references

Properties

edit

Sodium salicylate is of the salicylate family.

Uses

edit

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [5][6][7] and also necrosis.[8] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.[9]

References

edit
  1. ^ a b c "sodium salicylate". chemister.ru. Retrieved 8 April 2018.
  • ^ Chambers, Michael. "ChemIDplus - 54-21-7 - ABBQHOQBGMUPJH-UHFFFAOYSA-M - Sodium salicylate [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information". chem.sis.nlm.nih.gov. Retrieved 8 April 2018.
  • ^ Sigma-Aldrich Co., Sodium salicylate. Retrieved on 2014-05-26.
  • ^ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
  • ^ Klampfer, Lidija; Jörg Cammenga; Hans-Georg Wisniewski; Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood. 93 (7): 2386–94. doi:10.1182/blood.V93.7.2386. PMID 10090950.
  • ^ Rae, Colin; Susana Langa; Steven J. Tucker; David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA. 104 (31): 12790–5. Bibcode:2007PNAS..10412790R. doi:10.1073/pnas.0701437104. PMC 1937545. PMID 17646662.
  • ^ Stark, Lesley A.; et al. (May 2007). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis. 28 (5): 968–76. doi:10.1093/carcin/bgl220. PMID 17132819.
  • ^ Schwenger, Paul; Edward Y. Skolnik; Jan Vilcek (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry. 271 (14): 8089–94. doi:10.1074/jbc.271.14.8089. PMID 8626494.
  • ^ Samson, James. "Vacuum Ultraviolet Spectroscopy" (PDF). Pied Publications. Archived from the original (PDF) on October 16, 2006. Retrieved July 26, 2012.
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    Last edited on 19 November 2023, at 00:42  





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